Ethosuximide vs valproate: 80% or greater reduction in seizure frequency ‐ not reported
- Population
- absence seizures in children and adolescents
- Intervention
- Ethosuximide
- Comparison
- valproate
- Outcome
- 80% or greater reduction in seizure frequency ‐ not reported
It is very uncertain whether ethosuximide changes 80% or greater reduction in seizure frequency compared with valproate (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Ethosuximide vs valproate 80% or greater reduction in seizure frequency · absence seizures in children and adolescents It is very uncertain whether ethosuximide changes 80% or greater reduction in seizure frequency compared with valproate (very low certainty). Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents (2021) · Cochrane Headline outcomes only | RR 0.7 [0.19, 2.59] | 1 study · 29 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents 2021 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Ethosuximide vs lamotrigine · absence seizures in children and adolescents · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.