Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

311 questions · 323 findings · 30 reviews

No studies found 47 · 14.6%GRADE not reported 21 · 6.5%Very low 91 · 28.2%Low 65 · 20.1%Moderate 82 · 25.4%High 17 · 5.3%

Macrolide+tetracycline vs macrolides

Number of people experiencing one or more exacerbations, Drug resistance/microbial sensitivity (as reported by trialists), including emergence of atypical bacteria, Number of participants colonised with Pseudomonas aeruginosa · patients with chronic obstructive pulmonary disease

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings. Surgery (percutaneous wire fixation) vs not surgery (cast only)

Serious adverse events (typically more serious complications) ( · children with displaced distal radius fracture with intact or involved or displaced ulna fracture (both‐bone fracture)

It is very uncertain whether summary of findings. Surgery (percutaneous wire fixation) changes serious adverse events (typically more serious complications) ( compared with not surgery (cast only) (very low certainty).

1 finding from 1 review

Intervention not reported

Typical BAC: 4+ months—individual face‐to‐face normative feedback · university or college students

The intervention showed no clear difference in typical BAC: 4+ months—individual face‐to‐face normative feedback (moderate certainty).

1 finding from 1 review

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Signs and symptoms of atypical swallowing and speech production disturbances · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

QUETIAPINE vs Typical antipsychotics

Global state: No clinically significant response (as defined by the original studies) · patients with schizophrenia

Quetiapine showed no clear difference in global state No clinical significant response as defined by the… compared with typical antipsychotics (moderate certainty).

1 finding from 1 review