Atypical vs atypical antipsychotics (only short term)
No improvement (clozapine vs olanzapine) · people with psychosis
1 finding from 1 review
- no estimate extracted1 study · 39 participantsHigh
Findings
What do systematic reviews say?
311 questions · 323 findings · 30 reviews
No studies found 47 · 14.6%GRADE not reported 21 · 6.5%Very low 91 · 28.2%Low 65 · 20.1%Moderate 82 · 25.4%High 17 · 5.3%
Atypical vs atypical antipsychotics (only short term)
Use of other antipsychotics · people with psychosis
1 finding from 1 review
- no estimate extracted1 study · 28 participantsModerate
Atypical vs atypical antipsychotics (only short term)
Drug‐induced diabetes (clozapine vs olanzapine) · people with psychosis
1 finding from 1 review
- no estimate extracted1 study · 28 participantsModerate
Atypical vs atypical antipsychotics (only short term)
Elevated prolactin (risperidone vs quetiapine) · people with psychosis
1 finding from 1 review
- no estimate extracted1 study · 22 participantsModerate
Atypical vs atypical antipsychotics (only short term)
Weight gain · people with psychosis
1 finding from 1 review
- no estimate extracted1 study · 76 participantsHigh
Atypical vs atypical antipsychotics (only short term)
Leaving the study early because of weight gain (risperidone vs olanzapine) · people with psychosis
1 finding from 1 review
- no estimate extracted1 study · 19 participantsLow
Atypical vs typical antipsychotics (only short term)
Worse or no improvement · people with psychosis
1 finding from 1 review
- no estimate extracted1 study · 21 participantsLow
Atypical vs typical antipsychotics (only short term)
Adverse effects ‐ anticholinergic effects · people with psychosis
1 finding from 1 review
- no estimate extracted1 study · 40 participantsModerate
Atypical vs typical antipsychotics (only short term)
Drop in the absolute neutrophil count below 1500 per mm3 · people with psychosis
1 finding from 1 review
- no estimate extracted1 study · 21 participantsVery low
Atypical vs typical antipsychotics (only short term)
Adverse effects: Leaving the study early · people with psychosis
1 finding from 1 review
- no estimate extracted1 study · 21 participantsModerate
Atypical vs atypical antipsychotics (only short term)
No improvement (risperidone vs olanzapine) · people with psychosis
1 finding from 1 review
- no estimate extracted2 studies · 111 participantsModerate
Typical vs atypical antipsychotics
All‐cause mortality · delirious patients
Typical showed no clear difference in mortality compared with atypical antipsychotics (moderate certainty).
1 finding from 1 review
- Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes onlyRR 1.71 [0.82, 3.53]4 studies · 342 participantsModerate
Typical vs atypical antipsychotics
Length of hospital stay · delirious patients
The review found no eligible studies for this question.
1 finding from 1 review
- Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Typical vs atypical antipsychotics
Adverse effects/events ‐ extrapyramidal symptoms ‐ medium term Number of instances of extrapyramidal symptoms · delirious patients
It is very uncertain whether typical changes adverse Effects ‐ EPS compared with atypical antipsychotics (very low certainty).
1 finding from 1 review
- Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes onlyRR 12.16 [0.55, 269.52]2 studies · 198 participantsVery low
Typical vs atypical antipsychotics
Duration of delirium Days · delirious patients
The review found no eligible studies for this question.
1 finding from 1 review
- Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Typical vs atypical antipsychotics
Delirium resolution DRS, DRS‐R981 · delirious patients
Typical showed no clear difference in delirium resolution DRS, DRS‐R981 compared with atypical antipsychotics (moderate certainty).
1 finding from 1 review
- Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes onlyRR 1.1 [0.79, 1.52]5 studies · 349 participantsModerate
Typical vs atypical antipsychotics
Severity of delirium · delirious patients
1 finding from 1 review
- Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes onlyno estimate extracted7 studies · 542 participantsModerate
Atypical vs Typical antipsychotics
Diabetes · Adults with mental disorders in low‐ and middle‐income countries
Atypical showed no clear difference in diabetes (ADA criteria) (6 weeks) compared with typical antipsychotic medications (low certainty).
1 finding from 1 review
- Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income countries 2021 · Cochrane Headline outcomes onlyRR 0.5 [0.03, 7.73]1 study · 93 participantsLow
Atypical vs Typical antipsychotics
Drop‐out Objective · Adults with mental disorders in low‐ and middle‐income countries
Atypical showed no clear difference in drop‐outs (6 to 54 weeks) compared with typical antipsychotic medications (low certainty).
1 finding from 1 review
- Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income countries 2021 · Cochrane Headline outcomes onlyRR 1.31 [0.63, 2.69]2 studies · 144 participantsLow
Atypical vs Typical antipsychotics
Fasting blood glucose (mg/dL) · Adults with mental disorders in low‐ and middle‐income countries
1 finding from 1 review
- Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income countries 2021 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 211 participantsModerate