Cochrane · systematic review · CD005594
Antipsychotics for treatment of delirium in hospitalised non‐ICU patients
Burry, L, Mehta, S, Perreault, MM, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
8
No studies
4
Included studies
NR
No studies 4 · 33.3%Ungraded 0 · 0%Very low 4 · 33.3%Low 0 · 0%Moderate 4 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antipsychotics versus nonantipsychotics or placebo for the treatment of delirium in hospitalised patients
Population: delirious patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration of delirium Antipsychotics vs nonantipsychotics or placebo | no estimate extracted | NR | No studies |
Delirium severity DRS, DRS‐R98, MDAS1 Antipsychotics vs nonantipsychotics or placebo | no estimate extracted | 4 studies · 494 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Delirium resolution DRS, DRS‐R981 Antipsychotics vs nonantipsychotics or placebo | RR 0.95 [0.3, 2.98] | 3 studies · 247 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Mortality Antipsychotics vs nonantipsychotics or placebo | RR 1.29 [0.73, 2.27] | 3 studies · 319 participants | Moderate |
Hospital length of stay Antipsychotics vs nonantipsychotics or placebo | no estimate extracted | NR | No studies |
Adverse Effects ‐ EPS Extrapyramidal Symptom Rating Scale, or not reported Antipsychotics vs nonantipsychotics or placebo | RR 1.7 [0.04, 65.57] | 3 studies · 247 participants | Very low Downgraded: risk of bias, imprecision |
Typical versus atypical antipsychotics for treatment of delirium in hospitalised patients
Population: delirious patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration of delirium Typical vs atypical antipsychotics | no estimate extracted | NR | No studies |
Delirium resolution DRS, DRS‐R981 Typical vs atypical antipsychotics | RR 1.1 [0.79, 1.52] | 5 studies · 349 participants | Moderate Downgraded: risk of bias |
Delirium severity DRS, DRS‐R981 Typical vs atypical antipsychotics | no estimate extracted | 7 studies · 542 participants | Moderate Downgraded: risk of bias |
Mortality Typical vs atypical antipsychotics | RR 1.71 [0.82, 3.53] | 4 studies · 342 participants | Moderate |
Hospital length of stay Typical vs atypical antipsychotics | no estimate extracted | NR | No studies |
Adverse Effects ‐ EPS Typical vs atypical antipsychotics | RR 12.16 [0.55, 269.52] | 2 studies · 198 participants | Very low Downgraded: risk of bias, imprecision |