Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

141 questions · 155 findings · 23 reviews · Headline outcomes only

No studies found 50 · 32.3%GRADE not reported 1 · 0.6%Very low 27 · 17.4%Low 39 · 25.2%Moderate 28 · 18.1%High 10 · 6.5%

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo

Participant assessment of success by analysing scores and scales ‐ 4 weeks · glabellar lines

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher participant assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo

Physician assessment of success by analysing scores and scales ‐ 4 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher physician assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo

Participant assessment of success by analysing scores and scales ‐ 20 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines

Summary of Findings Table ‐ AbobotulinumtoxinA 50U leads to higher participant assessment of success by analysing scores and scales ‐… compared with placebo (high certainty).

1 finding from 1 review

Intervention not reported

Maternal pain score or pain measured in labour (VAS at 60 minutes (at peak of contraction))
1 finding from 1 review

Baclofen vs placebo

Neuromusculoskeletal and movement‐related functions up to 6 hours after treatment (Measured by spasm and deep tendon reflex scores, 0‐5, with 0 being no reflexes and 5 being clonus, or repeated involuntary muscle contractions) · adults with traumatic brain injury with spasticity in their arms and legs
1 finding from 1 review

Cuffed vs uncuffed tubes

Postextubation stridor (defined as any inspiratory sound or persistent barking, or presence of sternal or intercostal retractions postextubation) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes postextubation stridor (defined as any inspiratory sound or… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Intervention not reported

Maximum voluntary contraction in dystrophinopathies % · patients with muscular dystrophies
1 finding from 1 review

Intervention not reported

Maximum voluntary contraction in myotonic dystrophy type 1 % · patients with muscular dystrophies
1 finding from 1 review

Intervention not reported

Maximum voluntary contraction in myotonic dystrophy type 2 % · patients with muscular dystrophies
1 finding from 1 review

Intervention not reported

Maximum voluntary contraction in mitochondrial diseases % · patients with metabolic myopathies
1 finding from 1 review

Intervention not reported

Maximum voluntary contraction in glycogen storage disease type V % · patients with metabolic myopathies
1 finding from 1 review

Intervention not reported

Upper extremity maximum voluntary isometric contraction score at 3 months Quantitative Muscle Assessment (QMA) system. Data were normalized, summed and averaged to yield an U/E megascore (higher is better). · people with amyotrophic lateral sclerosis or motor neuron disease
1 finding from 1 review

Intervention not reported

Lower extremity maximum voluntary isometric contraction score at 3 months Quantitative Muscle Assessment (QMA) system. Data were normalized, summed and averaged to yield a L/E megascore (higher is better). · people with amyotrophic lateral sclerosis or motor neuron disease
1 finding from 1 review