evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

270 questions · 565 findings · 37 reviews

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 4 · 0.7%GRADE not reported 463 · 81.9%Very low 27 · 4.8%Low 23 · 4.1%Moderate 29 · 5.1%High 19 · 3.4%

CPP-ACP vs No active treatment (control)

Average enamel surface roughness · Extracted human teeth with early/artificial enamel lesions (in vitro)

In vitro, CPP-ACP markedly reduced enamel surface roughness versus control (SMD -8.21, 95% CI -10.37 to -6.04; ungraded).

1 finding from 1 review

Women who experienced preterm birth vs Women who did not experience preterm birth (term)

Decayed, missing, filled surfaces (DMFS) · pregnant women

Women who experienced preterm birth did not have a significantly different DMFS than those who did not (mean difference -0.15, 95% CI -3.40 to 3.09; 3 studies; I2=89%); certainty of evidence not graded.

1 finding from 1 review
  • Dental caries and preterm birth: a systematic review and meta-analysis. 2018 All outcomes
    Pregnant women assessed around delivery in observational studies across multiple countries (Mexico, Malawi, India, France, Jordan, Finland, Tanzania); mostly retrospective cohort and case-control designs
    MD -0.15 [-3.40, 3.09]
    3 studies · 2594 participants
    GRADE not reported

Fluorides combined with CPP-ACP vs Fluorides alone (monotherapy)

Total lesion area divided by total surface area (visual) · Patients with early caries lesions in permanent teeth (non-fluoridated water area)

Adding CPP-ACP to fluorides did not significantly change the lesion-area outcome for smooth-surface early caries lesions versus fluorides alone; not GRADE-rated.

1 finding from 1 review

38% silver diamine fluoride vs Active dentine caries at baseline (single-arm before vs after proportion)

Arrest of dentine caries · Children with dentine caries in primary and permanent teeth

Professionally applied 38% silver diamine fluoride arrested about two-thirds of active dentine caries surfaces in children (pooled proportion 65.9%, 95% CI 41.2% to 90.7%; 5 studies); certainty was not GRADE-rated and heterogeneity was very high (I2=96%).

1 finding from 1 review

Conventional bitewing radiography, F-speed film vs Histological validation of dental tissues (gold standard)

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)

Under in vitro conditions, conventional F-speed bitewing radiography had a summary ROC AUC of 0.72 for proximal caries detection at the caries detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Laser fluorescence (DIAGNOdent 2190/pen) vs Histological validation of dental tissues (gold standard)

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)

Under in vitro conditions, laser fluorescence (DIAGNOdent 2190) had a summary ROC AUC of 0.83 for proximal caries detection at the dentin detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Conventional bitewing radiography (E-speed film) vs Histological validation of dental tissues (gold standard)

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)

Under in vitro conditions, conventional E-speed bitewing radiography had a pooled sensitivity of 0.42 (95% CI 0.28, 0.57) for proximal caries detection at the caries detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Laser fluorescence (DIAGNOdent 2095) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces

In in vitro, laser fluorescence (DIAGNOdent 2095) pooled summary ROC AUC was 0.81 for occlusal caries at the caries detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Conventional bitewing radiography (E-speed film) vs Histological validation of dental tissues (gold standard)

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)

Under in vitro conditions, conventional E-speed bitewing radiography had a pooled diagnostic odds ratio of 31.40 (95% CI 14.31, 68.93) for proximal caries detection at the dentin detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Digital bitewing radiography, phosphor plate (PSP) vs Direct visual examination after tooth separation or bioptical cavity preparation

Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo)

Under in vivo conditions, phosphor-plate digital bitewing radiography had a pooled specificity of 0.60 (95% CI 0.20, 0.90) for proximal caries detection at the dentin detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Laser fluorescence (DIAGNOdent 2190/pen) vs Direct visual examination after tooth separation or bioptical cavity preparation

Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo)

Under in vivo conditions, laser fluorescence (DIAGNOdent 2190) had a pooled specificity of 0.60 (95% CI 0.15, 0.93) for proximal caries detection at the dentin detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Conventional bitewing radiography, F-speed film vs Histological validation of dental tissues (gold standard)

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)

Under in vitro conditions, conventional F-speed bitewing radiography had a pooled diagnostic odds ratio of 8.7 (95% CI 4.2, 18.1) for proximal caries detection at the dentin detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Conventional bitewing radiography (D-speed film) vs Histological validation of dental tissues (gold standard)

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)

Under in vitro conditions, conventional D-speed bitewing radiography had a pooled specificity of 0.99 (95% CI 0.96, 0.999) for proximal caries detection at the dentin detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Digital bitewing radiography, sensor-based (CCD/CMOS) vs Histological validation of dental tissues (gold standard)

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)

Under in vitro conditions, sensor-based digital bitewing radiography had a pooled diagnostic odds ratio of 5.01 (95% CI 2.83, 8.88) for proximal caries detection at the caries detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Visual examination (VE) vs Cavity preparation or biopsy (operative validation)

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

In in vivo, visual examination pooled summary ROC AUC was 0.70 for occlusal caries at the caries detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Laser fluorescence (DIAGNOdent 2095) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces

In in vitro, laser fluorescence (DIAGNOdent 2095) pooled summary ROC AUC was 0.79 for occlusal caries at the dentin detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Conventional bitewing radiography (E-speed film) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces

In in vitro, conventional bitewing radiography (E-speed) pooled sensitivity was 0.48 (95% CI 0.21 to 0.77) for occlusal caries at the dentin detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Laser fluorescence (DIAGNOdent 2095) vs Cavity preparation or biopsy (operative validation)

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

In in vivo, laser fluorescence (DIAGNOdent 2095) pooled diagnostic odds ratio was 18.33 (95% CI 7.57 to 44.37) for occlusal caries at the caries detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Digital bitewing radiography, sensor-based (CCD/CMOS) vs Histological validation of dental tissues (gold standard)

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)

Under in vitro conditions, sensor-based digital bitewing radiography had a pooled diagnostic odds ratio of 12.84 (95% CI 6.56, 25.13) for proximal caries detection at the dentin detection level; ungraded.

4 findings from 1 review
Show 1 more finding