Severe exacerbations (requiring ED visits or systemic steroids, or both) Number of people having ≥ 1 exacerbations requiring an ED visit or systemic steroids, or both. Classification varied across studies. Weighted mean study duration: 35 weeks · adults and children with chronic asthma
Macrolides probably leads to lower severe exacerbations (requiring ED visits or systemic steroids, or… compared with placebo (moderate certainty).
1 finding from 1 review
Asthma exacerbations requiring hospitalisation or a course of steroids · people with asthma
The review found no eligible studies for this question.
1 finding from 1 review
Statins for asthma 2020 · Cochrane Headline outcomes only no estimate extracted
Studies not reported
No studies found
Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease
Fixed‐dose combination aclidinium/formoterol showed no clear difference in exacerbations requiring steroids or antibiotics or both: number of… compared with aclidinium alone (moderate certainty).
1 finding from 1 review
Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease
Fixed‐dose combination aclidinium/formoterol showed no clear difference in exacerbations requiring steroids or antibiotics or both: number of… compared with placebo (moderate certainty).
1 finding from 1 review
Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease
Fixed‐dose combination aclidinium/formoterol leads to lower exacerbations requiring steroids or antibiotics or both: number of… compared with formoterol (high certainty).
1 finding from 1 review
Mean dose of inhaled corticosteroids per person per day (BUD equivalent mcg/day) · people with asthma
1 finding from 1 review
Mean daily use of oral corticosteroids per person per day · people with asthma
1 finding from 1 review
Intervention not reported
Number of participants requiring oral corticosteroids over the study period · Adults from minority groups with doctor diagnosed asthma
It is very uncertain whether the intervention changes number of participants requiring oral corticosteroids over the study… (very low certainty).
1 finding from 1 review
Courses of oral corticosteroids · patients with chronic obstructive pulmonary disease
Self‐management interventions including action plans for exacerbations showed no clear difference in courses of oral steroids compared with usual care (low certainty).
1 finding from 1 review
Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease
Umeclidinium bromide leads to lower number of participants with exacerbations requiring steroids,… compared with placebo (high certainty).
1 finding from 1 review
Courses of oral corticosteroids · acute exacerbations of chronic obstructive pulmonary disease
1 finding from 1 review
Intervention not reported
Exacerbations requiring oral corticosteroids 7.3‐month · people with asthma
The intervention showed no clear difference in exacerbations requiring oral corticosteroids 7.3‐month (low certainty).
1 finding from 1 review
Intervention not reported
Exacerbations requiring oral corticosteroids3 months · adults or children with asthma
The intervention showed no clear difference in exacerbations requiring oral corticosteroids3 months (low certainty).
1 finding from 1 review
Mean exacerbations requiring a course of oral corticosteroids · adults and adolescents with asthma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Number of participants experiencing one or more episode requiring treatment with oral steroids · episodic viral wheeze in children
Maintenance LTRA showed no clear difference in number of participants experiencing one or more episode requiring… compared with placebo (moderate certainty).
1 finding from 1 review
Number of participants experiencing one or more episode requiring treatment with oral steroids · episodic viral wheeze in children
Intermittent LTRA showed no clear difference in number of participants experiencing one or more episode requiring… compared with placebo (moderate certainty).
1 finding from 1 review
Exacerbations requiring oral corticosteroids ‐ School‐age children · School‐aged children and adults
Intermittent ICS showed no clear difference in exacerbations requiring oral corticosteroids ‐ School‐age children compared with placebo (low certainty).
1 finding from 1 review
Exacerbations requiring oral corticosteroids ‐ adults · School‐aged children and adults
Intermittent ICS showed no clear difference in exacerbations requiring oral corticosteroids ‐ adults compared with placebo (low certainty).
1 finding from 1 review
Mean exacerbations requiring a course of oral corticosteroids · Preschool children (<6 years)
Intermittent ICS probably leads to lower exacerbations requiring oral corticosteroids compared with placebo (moderate certainty).
1 finding from 1 review
Exacerbations requiring steroids, antibiotics or both · patients with stable chronic obstructive pulmonary disease
Aclidinium bromide showed no clear difference in exacerbations requiring steroids, antibiotics or both compared with placebo (moderate certainty).
1 finding from 1 review