Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

327 questions · 337 findings · 47 reviews · Headline outcomes only

No studies found 69 · 20.5%GRADE not reported 35 · 10.4%Very low 49 · 14.5%Low 73 · 21.7%Moderate 63 · 18.7%High 48 · 14.2%

Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening

All‐cause mortality ‐ Annual chest x‐ray plus 4‐monthly cytology versus annual x‐ray alone · Patients with lung cancer

Lung cancer screening with chest radiography +/‐ sputum cytology showed no clear difference in all‐cause mortality ‐ Annual chest x‐ray plus 4‐monthly cytology… compared with less intense screening (high certainty).

1 finding from 1 review

Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening

Lung cancer 5‐year survival ‐ Annual chest x‐ray plus 4‐monthly cytology versus annual x‐ray alone · Patients with lung cancer

Lung cancer screening with chest radiography +/‐ sputum cytology probably leads to lower lung cancer 5‐year survival ‐ Annual chest x‐ray plus 4‐monthly… compared with less intense screening (moderate certainty).

1 finding from 1 review

Universal screening vs case finding

Thyroid dysfunction diagnosed in pregnancy: hyperthyroid · women during pregnancy

Universal screening showed no clear difference in thyroid dysfunction diagnosed in pregnancy: hyperthyroid compared with case finding (moderate certainty).

1 finding from 1 review

Intervention not reported

Invitation versus control: uptake of screening · women for cervical screening

The intervention probably leads to higher invitation versus control: uptake of screening (moderate certainty).

1 finding from 1 review

Intervention not reported

GP invitation letter versus invitation letter from other authority sources: uptake of screening · women for cervical screening

It is very uncertain whether the intervention changes GP invitation letter versus invitation letter from other authority… (very low certainty).

1 finding from 1 review