Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

143 questions · 151 findings · 35 reviews · Headline outcomes only

No studies found 19 · 12.6%GRADE not reported 30 · 19.9%Very low 27 · 17.9%Low 39 · 25.8%Moderate 33 · 21.9%High 3 · 2%

Psychotherapy as an adjunct to usual care vs usual care

Response (50% reduction in BDI) long term (longer than 12 months)* · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care may leads to higher response (50% reduction in BDI) long term (longer than 12 months)* compared with usual care alone (low certainty).

1 finding from 1 review

Intervention not reported

Behavioural outcome: colorectal cancer screening IVR, unidirectional ATCS versus usual care or letter at longer (9‐12 months) · participants at risk for breast, colorectal or cervical cancer; or osteoporosis

The intervention showed no clear difference in behavioural outcome: colorectal cancer screening IVR, unidirectional… (moderate certainty).

1 finding from 1 review

CBT vs WAIT LIST

Remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting criteria for DSM or ICD anxiety diagnosis at the end of the trial. · children and adolescents with anxiety disorders

CBT probably leads to higher remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting… compared with wait‐list (moderate certainty).

1 finding from 1 review

CBT vs active control

Remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting criteria for DSM or ICD anxiety diagnosis at the end of the trial. · children and adolescents with anxiety disorders

CBT showed no clear difference in remission of anxiety diagnoses (ITT) analysis i.e. no longer meeting… compared with active controls (moderate certainty).

1 finding from 1 review

CBT vs treatment

Remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting criteria for DSM or ICD anxiety diagnosis at the end of the trial. · children and adolescents with anxiety disorders

CBT showed no clear difference in remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting… compared with treatment (moderate certainty).

1 finding from 1 review

Mortality: prone position vs supine

Subgroup analysis of longer‐term mortality: severe hypoxaemiaAlive or dead · adults with acute respiratory failure

Mortality: prone position probably leads to lower subgroup analysis of longer‐term mortality: severe hypoxaemiaAlive… compared with supine (moderate certainty).

1 finding from 1 review

Mortality: prone position vs supine

Subgroup analysis of longer‐term mortality: lower tidal volume ventilationAlive or dead · adults with acute respiratory failure

Mortality: prone position probably leads to lower subgroup analysis of longer‐term mortality: lower tidal volume… compared with supine (moderate certainty).

1 finding from 1 review

Mortality: prone position vs supine

Subgroup analysis of longer‐term mortality: ARDS onlyAlive or dead · adults with acute respiratory failure

Mortality: prone position showed no clear difference in subgroup analysis of longer‐term mortality: ARDS onlyAlive or dead compared with supine (moderate certainty).

1 finding from 1 review

Mortality: prone position vs supine

Subgroup analysis of longer‐term mortality: ≥ 16 hours/d proneAlive or dead · adults with acute respiratory failure

Mortality: prone position probably leads to lower subgroup analysis of longer‐term mortality: ≥ 16 hours/d proneAlive… compared with supine (moderate certainty).

1 finding from 1 review