Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

108 questions · 112 findings · 9 reviews · Pain, Palliative and Supportive Care

No studies found 7 · 6.3%GRADE not reported 6 · 5.4%Very low 42 · 37.5%Low 40 · 35.7%Moderate 13 · 11.6%High 4 · 3.6%

Perioperative infraorbital nerve block vs Intravenous analgesia

Need for analgesic prescription for pain (supplemental analgesic requirements) · Children up to 13 years of age, undergoing cleft lip repair surgery

It is very uncertain whether perioperative infraorbital nerve block changes need for analgesic prescription for pain (supplemental analgesic… compared with intravenous analgesia (very low certainty).

1 finding from 1 review

Perioperative infraorbital nerve block vs Intravenous analgesia

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review

Ibuprofen vs placebo

At least 50% reduction in pain · health problem or population

It is very uncertain whether summary of Findings Table ‐ Ibuprofen changes number of participants with at least 50% pain relief at 4 hours compared with placebo (very low certainty).

2 findings from 1 review

Summary of Findings Table ‐ Ibuprofen 300 mg vs paracetamol

Number of participants reporting an adverse event · health problem or population

It is very uncertain whether summary of Findings Table ‐ Ibuprofen 300 mg changes number of participants reporting or experiencing any adverse event compared with active comparator (acetaminophen) (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Ibuprofen 300 mg vs paracetamol

At least 50% reduction in pain · health problem or population

It is very uncertain whether summary of Findings Table ‐ Ibuprofen 300 mg changes number of participants with at least 50% pain relief at 4 hours compared with active comparator (acetaminophen) (very low certainty).

2 findings from 1 review