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Evidence found and GRADE certainty

471 questions · 539 findings · 69 reviews

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No studies found 154 · 28.6%GRADE not reported 121 · 22.4%Very low 117 · 21.7%Low 100 · 18.6%Moderate 43 · 8%High 4 · 0.7%

Resin-modified glass ionomer fissure sealant plus oral health education vs Fluoride varnish plus oral health education

Change in DMF increment on occlusal surfaces of first permanent molars · Children and adolescents (general population, aged under 20 years)

Resin-modified glass ionomer fissure sealant plus oral health… showed no clear difference in change in DMF increment on occlusal surfaces of first permanent molars compared with fluoride varnish plus oral health education; GRADE not reported.

2 findings from 1 review

Health education vs usual care

Proportion of children who received the vaccine under study (BCG) · children under 5 years of age

Health education showed no clear difference in proportion of children who received the vaccine under study (BCG) compared with routine care (moderate certainty).

1 finding from 1 review

Health education vs usual care

Proportion of children who received the vaccine under study (measles) · children under 5 years of age

Health education may leads to higher proportion of children who received the vaccine under study (measles… compared with routine care (low certainty).

1 finding from 1 review

Health education vs usual care

Proportion of children who received other vaccine under study (BCG + DTP3 + OPV) · children under 5 years of age

Health education showed no clear difference in proportion of children who received other vaccine under study (BCG +… compared with routine care (low certainty).

1 finding from 1 review

Health education vs usual care

Proportion of children under 5 years of age fully immunised with all scheduled vaccines · children under 5 years of age

Health education may leads to higher proportion of children under 5 years of age fully immunised with all… compared with routine care (low certainty).

1 finding from 1 review

Gamified oral health interventions (mobile apps, serious games, augmented reality, game-based education) vs Conventional or traditional oral health education, or non-gamified interventions (comparator varied; several studies were single-arm/uncontrolled)

Oral health knowledge (1-9 scale) · Children or adolescents

Gamified interventions appear to improve children's oral health knowledge compared with conventional education, but the evidence is narrative and ungraded.

1 finding from 1 review
  • The Application of Gamification in Children's Oral Health Management: Systematic Review. 2025 All outcomes
    Post-intervention (predominantly short-term; long-term follow-up in a minority of studies) · School-based settings, specialized dental clinics, and home-based environments
    The effectiveness of digital-based interventions was generally positive, with 38% (9/24) of the experimental studies reporting improvements in oral health knowledge and behaviors; game-based teaching significantly…
    9 studies
    GRADE not reported

Community health educational interventions vs control

Neonatal mortality · developing countries

Community health educational interventions may leads to lower neonatal mortality compared with control (low certainty).

2 findings from 1 review

Community health educational interventions vs control

Early neonatal mortality · developing countries

It is very uncertain whether community health educational interventions changes early neonatal mortality compared with control (very low certainty).

2 findings from 1 review

Community health educational interventions vs control

Late neonatal mortality · developing countries

It is very uncertain whether community health educational interventions changes late neonatal mortality compared with control (very low certainty).

2 findings from 1 review