Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

90 questions · 90 findings · 23 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 39 · 43.3%GRADE not reported 0 · 0%Very low 22 · 24.4%Low 22 · 24.4%Moderate 5 · 5.6%High 2 · 2.2%

Zinc vs placebo

Need for antibiotics days of antibiotic use · children with cystic fibrosis

It is very uncertain whether summary of findings: Zinc supplementation changes need for antibiotics number of days on IV or oral antibiotics compared with placebo (very low certainty).

1 finding from 1 review

Inhaled corticosteroids vs placebo

Respiratory exacerbations: number of days on intravenous antibiotics for respiratory exacerbations · adults and children with cystic fibrosis

It is very uncertain whether summary of findings: inhaled corticosteroids changes respiratory exacerbations: number of days on intravenous antibiotics… compared with placebo (very low certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Number of immediate (less than 24 hours) and delayed (24 hours to 10 days) postoperative bleeding episodes requiring intervention · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Quality of life: Days of work lost per crisis · adults and children with sickle cell disease

The intervention showed no clear difference in quality of life: Days of work lost per crisis (moderate certainty).

1 finding from 1 review