Cochrane · systematic review · CD002008
Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults
Baldwin, C, de van der Schueren, MAE, Kruizenga, HM, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
35
current version
GRADE rated
30
No studies
5
Included studies
NR
No studies 5 · 14.3%Ungraded 0 · 0%Very low 2 · 5.7%Low 26 · 74.3%Moderate 2 · 5.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Dietary advice compared with no advice for disease‐related malnutrition in adults
Population: adults with disease‐related malnutrition
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Dietary advice vs no advice | RR 0.87 [0.26, 2.96] | 7 studies · 574 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Number of people admitted or readmitted to hospital Dietary advice vs no advice | no estimate extracted | NR | No studies |
Length of hospital stay (days) Dietary advice vs no advice | no estimate extracted | 1 study · 148 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Complications Dietary advice vs no advice | no estimate extracted | 1 study · 148 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in weight (kg) Dietary advice vs no advice | no estimate extracted | 10 studies · 802 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in fat‐free mass (kg) Dietary advice vs no advice | no estimate extracted | 2 studies · 98 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in global QoL score Dietary advice vs no advice | no estimate extracted | 5 studies · 421 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Dietary advice compared with oral nutritional supplements for disease‐related malnutrition in adults
Population: adults with disease‐related malnutrition
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Dietary advice vs oral nutritional supplements | RR 0.66 [0.34, 1.26] | 8 studies · 576 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Number of people admitted or re‐admitted to hospital Dietary advice vs oral nutritional supplements | RR 0.36 [0.04, 3.24] | 1 study · 50 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Length of hospital stay (days) Â Dietary advice vs oral nutritional supplements | no estimate extracted | NR | No studies |
Complications  Dietary advice vs oral nutritional supplements | no estimate extracted | NR | No studies |
Change in weight (kg) Dietary advice vs oral nutritional supplements | no estimate extracted | 9 studies · 517 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in fat‐free mass (kg) Dietary advice vs oral nutritional supplements | no estimate extracted | NR | No studies |
Change in global QoL score Dietary advice vs oral nutritional supplements | no estimate extracted | 4 studies · 283 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Dietary advice compared with dietary advice plus oral nutritional supplements for disease‐related malnutrition in adults
Population: adults with disease‐related malnutrition
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Dietary advice vs dietary advice plus oral nutritional supplements | RR 0.92 [0.47, 1.8] | 10 studies · 777 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Number of people admitted or re‐admitted to hospital Dietary advice vs dietary advice plus oral nutritional supplements | RR 1.7 [1.04, 2.77] | 1 study · 114 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Length of hospital stay (days) Dietary advice vs dietary advice plus oral nutritional supplements | no estimate extracted | 2 studies · 202 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Complications Dietary advice vs dietary advice plus oral nutritional supplements | RR 0.75 [0.56, 0.99] | 3 studies · 317 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in weight (kg) Dietary advice vs dietary advice plus oral nutritional supplements | no estimate extracted | 14 studies · 931 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in fat‐free mass (kg) Dietary advice vs dietary advice plus oral nutritional supplements | no estimate extracted | 3 studies · 187 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Change in global QoL score Dietary advice vs dietary advice plus oral nutritional supplements | no estimate extracted | 4 studies · 321 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Dietary advice plus supplements if required compared with no advice for disease‐related malnutrition in adults
Population: adults with disease‐related malnutrition
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Dietary advice plus supplements if required vs no advice | RR 0.82 [0.58, 1.16] | 15 studies · 1261 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Number of people admitted or re‐admitted to hospital Dietary advice plus supplements if required vs no advice | RR 0.83 [0.59, 1.15] | 7 studies · 673 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Length of hospital stay (days) Dietary advice plus supplements if required vs no advice | no estimate extracted | 3 studies · 400 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Complications Dietary advice plus supplements if required vs no advice | RR 0.56 [0.22, 1.46] | 2 studies · 280 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Change in weight (kg) Dietary advice plus supplements if required vs no advice | no estimate extracted | 17 studies · 1192 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Change in fat‐free mass (kg) Dietary advice plus supplements if required vs no advice | no estimate extracted | 4 studies · 262 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Change in global QoL score Dietary advice plus supplements if required vs no advice | no estimate extracted | 7 studies · 389 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Dietary advice plus supplements compared with no dietary advice plus no supplements for disease‐related malnutrition in adults
Population: adults with disease‐related malnutrition
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Dietary advice plus supplements vs no dietary advice plus no supplements | RR 0.91 [0.55, 1.52] | 7 studies · 797 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Number of people admitted or re‐admitted to hospital Dietary advice plus supplements vs no dietary advice plus no supplements | no estimate extracted | NR | No studies |
Length of hospital stay (days) Dietary advice plus supplements vs no dietary advice plus no supplements | no estimate extracted | 2 studies · 258 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Complications Dietary advice plus supplements vs no dietary advice plus no supplements | RR 0.42 [0.2, 0.89] | 1 study · 50 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Change in weight (kg) Dietary advice plus supplements vs no dietary advice plus no supplements | no estimate extracted | 8 studies · 620 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Change in fat‐free mass (kg) Dietary advice plus supplements vs no dietary advice plus no supplements | no estimate extracted | 3 studies · 130 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Change in global QoL score Dietary advice plus supplements vs no dietary advice plus no supplements | no estimate extracted | 4 studies · 357 participants | Very low Downgraded: risk of bias, imprecision, indirectness |