Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

83 questions · 85 findings · 14 reviews

No studies found 22 · 25.9%GRADE not reported 1 · 1.2%Very low 18 · 21.2%Low 28 · 32.9%Moderate 15 · 17.6%High 1 · 1.2%

Intervention not reported

Retained in naltrexone maintenance treatment or abstinent at 12 weeks ‐ Clonidine comparison · patients with opioid withdrawal

The intervention probably leads to higher retained in naltrexone maintenance treatment or abstinent at 12… (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs clonidine oral (4 μg/kg)

Number of children with clinical adverse event: drowsiness · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) probably leads to lower number of children with clinical adverse event: drowsiness compared with clonidine oral (4 μg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs clonidine oral (4 μg/kg)

Number of children with clinical adverse event: vertigo · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse event: vertigo compared with clonidine oral (4 μg/kg) (moderate certainty).

1 finding from 1 review

Buprenorphine vs clonidine

Drop‐out (end of treatment) · patients with opiate dependent adolescents

Buprenorphine showed no clear difference in drop out Number of participants who did not complete the… compared with clonidine (moderate certainty).

1 finding from 1 review