Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

288 questions · 290 findings · 74 reviews · Headline outcomes only

No studies found 56 · 19.3%GRADE not reported 21 · 7.2%Very low 61 · 21%Low 62 · 21.4%Moderate 39 · 13.4%High 51 · 17.6%

Summary of findings for subcutaneous terbutaline with continuation of oxytocic infusion vs cessation of oxytocic infusion without tocolytic agent

Abnormal FHR tracing · women who developed uterine hyperstimulation in labour with oxytocin augmentation, but without signs of fetal distress

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings for subcutaneous terbutaline vs no tocolytic agent, whilst awaiting emergency delivery

Abnormal FHR tracing · women in labour with signs of fetal distress and a fetal scalp pH < 7.25, for whom the decision had been made for emergency delivery

Summary of findings for subcutaneous terbutaline probably leads to lower abnormal FHR tracing compared with no tocolytic agent, whilst awaiting emergency delivery (moderate certainty).

1 finding from 1 review

Summary of findings for selective ß2‐adrenergic agonist vs no tocolytic agent, whilst awaiting emergency delivery

Abnormal FHR as defined by trial authors (FHR tracing not improved) · women with fetal distress for whom the decision had been made to delivery by emergency caesarean section

Summary of findings for selective ß2‐adrenergic agonist probably leads to lower abnormal FHR as defined by trial authors (FHR tracing not improved) compared with no tocolytic agent, whilst awaiting emergency delivery (moderate certainty).

1 finding from 1 review

Discontinued intravenous (IV) oxytocin stimulation vs continued IV oxytocin stimulation

Uterine tachysystole combined with abnormal fetal heart rate · pregnant women in latent phase of labour stimulated with oxytocin for with induction of labour. No exclusion criteria were applied in…

Discontinued intravenous (IV) oxytocin stimulation probably leads to lower uterine tachysystole combined with abnormal fetal heart rate compared with continued IV oxytocin stimulation (moderate certainty).

1 finding from 1 review

Discontinued intravenous (IV) oxytocin stimulation vs continued IV oxytocin stimulation

Intrapartum cardiotocography (CTG) abnormalities (suspicious/pathological CTGs) · pregnant women in latent phase of labour stimulated with oxytocin for with induction of labour. No exclusion criteria were applied in…

Discontinued intravenous (IV) oxytocin stimulation probably leads to lower intrapartum cardiotocography (CTG) abnormalities… compared with continued IV oxytocin stimulation (moderate certainty).

1 finding from 1 review

Intervention not reported

Abnormally large livers reduced to within normal limits, as measured by ultrasound · adults and children with cystic fibrosis‐related liver disease

The review found no eligible studies for this question.

1 finding from 1 review

Itraconazole (200 mg for 6 to 8 weeks) vs placebo

Adverse effects Mild abdominal pain and nausea Adverse effects Mild abnormal liver function · patients with Old World cutaneous leishmaniasis

It is very uncertain whether itraconazole (200 mg for 6 to 8 weeks) changes adverse effects Mild abdominal pain and nausea Adverse effects Mild… compared with placebo (very low certainty).

1 finding from 1 review

Mefloquine vs doxycycline

Abnormal thoughts or perceptions · Non‐immune adults and children travelling to malaria‐endemic settings

Mefloquine showed no clear difference in abnormal thoughts or perceptions compared with doxycycline; GRADE not reported.

1 finding from 1 review