What do systematic reviews say?

Macrolides vs no intervention

The review found no eligible studies for this question.

• Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Macrolides vs no intervention

The review found no eligible studies for this question.

• Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Macrolides vs placebo

Macrolides showed no clear difference in hospitalisation: all cause compared with placebo (low certainty).

• Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  OR 0.56 [0.19, 1.62]
  2 studies · 151 participants
  Low

Macrolides vs no intervention

The review found no eligible studies for this question.

• Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Macrolides vs no intervention

• Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 34 participants
  Low

Macrolides vs no intervention

The review found no eligible studies for this question.

• Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Macrolides vs placebo

Macrolides showed no clear difference in serious adverse events compared with placebo (low certainty).

• Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  OR 0.49 [0.2, 1.23]
  3 studies · 326 participants
  Low

Macrolides vs placebo

• Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 540 participants
  Low

Macrolides vs placebo

• Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 68 participants
  Moderate

Macrolides vs placebo

• Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 305 participants
  Low

Macrolides vs no intervention

Macrolides showed no clear difference in ≥ 1 exacerbation compared with no intervention (moderate certainty).

• Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  OR 0.31 [0.08, 1.15]
  1 study · 43 participants
  Moderate

Macrolides vs no intervention

The review found no eligible studies for this question.

• Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Macrolides vs no intervention

The review found no eligible studies for this question.

• Macrolide antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Macrolides vs other antibiotics

Macrolides showed no clear difference in clinical cure: syndromic approach compared with any other antibiotic (low certainty).

• Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
  RR 1.09 [0.97, 1.21]
  2 studies · 340 participants
  Low

Macrolides vs other antibiotics

Macrolides showed no clear difference in clinical cure: aetiological approach compared with any other antibiotic (low certainty).

• Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
  RR 1.06 [0.98, 1.15]
  5 studies · 348 participants
  Low

Macrolides vs other antibiotics

It is very uncertain whether macrolides changes clinical improvement: syndromic approach compared with any other antibiotic (very low certainty).

• Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
  RR 0.89 [0.52, 1.52]
  2 studies · 340 participants
  Very low

Macrolides vs other antibiotics

Macrolides showed no clear difference in clinical improvement: aetiological approach compared with any other antibiotic (low certainty).

• Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
  RR 0.8 [0.42, 1.51]
  3 studies · 187 participants
  Low

Macrolides vs other antibiotics

Macrolides showed no clear difference in microbiological cure compared with any other antibiotic (low certainty).

• Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
  RR 0.93 [0.74, 1.16]
  1 study · 45 participants
  Low

Macrolides vs other antibiotics

It is very uncertain whether macrolides changes minor adverse events compared with any other antibiotic (very low certainty).

• Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults 2017 · Cochrane Headline outcomes only
  RR 1.34 [0.24, 7.51]
  3 studies · 412 participants
  Very low

Tacrolimus vs cyclosporin

Tacrolimus showed no clear difference in mortality Mortality at latest compared with cyclosporin (low certainty).

• Tacrolimus versus cyclosporin as primary immunosuppression for lung transplant recipients 2013 · Cochrane Headline outcomes only
  RR 1.06 [0.75, 1.49]
  3 studies · 413 participants
  Low