Search review questions

Patient perception of pain and discomfort (VAS 0 to 100 mm) · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment · First visit

Total mortality · Adults with oral cavity cancer

New coronal carious lesions or fillings on permanent (first) molars (caries prevention) · Children with dental caries in permanent (first) molars · 18 months, Monse 2012 (SDF one-time, with toothbrushing programme)

secondary caries prevention · children with deep occlusal carious lesions in permanent molars · 12 months

Predictive performance for root caries increment (positive likelihood ratio, LR+) · Older adults (aged 52-95; mean 52-73) at risk of root caries increment · Follow-up >=1 year (included studies 1-5 years), Model development studies

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Beck,1992 [24]; model performance 5

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Hänsel Petersson,2015 [30]; model performance 1

MMP-2 activity · Human root and coronal carious dentin

Periapical pathosis incidence · Vital teeth · Bone level < 35%

Oral health-related quality of life (dichotomous: poor vs not) · Indians across all ages (children, adolescents, adults, elderly) · Adolescents 10-19 years (dichotomous)

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Angulo,1995 [13]; model performance 1

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Beck,1992 [24]; model performance 3

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Pang,2021 [19]; model performance 3

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Gao,2013 [29]; model performance 9

Secondary caries prevention in young permanent first molars · Children with deep occlusal caries in young permanent first molars (indirect pulp capping) · 12 months, Baraka 2022 (indirect pulp capping, Egypt)

Oral health-related quality of life · Adolescents aged 10-19 years

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Beck,1992 [24]; model performance 8

Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)

MMP-8 location/depth · Human ex vivo carious dentin

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Fontana,2011 [16]; model performance 6

Oral health-related quality of life · Adolescents aged 10-19 years

Pulp necrosis · Vital teeth restored with indirect restorations · Follow-up ≤5 to >10 years, Radiographic pulp-status assessment

Predictive performance of the Cariogram for caries increment (negative likelihood ratio, LR-) · Children/adolescents (coronal caries) and older adults (root caries); populations from areas with varying caries risk · Follow-up >=1 year (included studies 1-5 years), Model validation studies

Change in angulation of teeth adjacent to the space (molar and canine tipping/rotation) · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances

Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Fontana,2011 [16]; model performance 5

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Gao,2013 [29]; model performance 3

Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic…

Secondary caries (occurrence) · Patients requiring dental restoration; deciduous (primary) teeth · 2 or more years of follow-up

new active or inactive carious lesions · schoolchildren with caries in permanent first molars · 36 months

Pulp necrosis incidence · Vital teeth · Eugenol-based

secondary caries prevention · children with deep occlusal carious lesions in permanent molars · 12 months

Body mass index-for-age z score · Children aged 1–6 years · Mouth pain

Adverse events associated with treatment · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Fontana,2011 [16]; model performance 9

Root caries increment · Individuals of all ages · Follow-up ≥1 year, Ritter,2016 [22]; model performance 4

Secondary caries (occurrence) · Patients requiring dental restoration; permanent teeth · 2 or more years of follow-up

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Hänsel Petersson,2015 [30]; model performance 3

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Fontana,2011 [16]; model performance 11

Oral health-related quality of life · Adolescents aged 10-19 years

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Christian,2020 [27]; model performance 1

new carious lesions or fillings at tooth level · children with caries in permanent molars · 24 months

Secondary caries (occurrence) · Patients requiring dental restoration; deciduous (primary) teeth · 1 year of follow-up, Overall (all bioactive vs resin composite)

New coronal carious lesions or fillings on permanent (first) molars (caries prevention) · Children with dental caries in permanent (first) molars · 18 months, Monse 2012 (SDF one-time, no toothbrushing programme; Philippines)

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Fontana,2011 [16]; model performance 6

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 7

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Gao.2010 [17]; model performance 1

Recurrence · Adults with oral cavity or oropharyngeal cancer

Rate of orthodontic tooth movement during space closure stage (maxillary arch), mm/month · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment · Space closure stage

Stability: Little's Irregularity Index · People who had received fixed appliance orthodontic treatment · 12 months, upper and lower arches