Findings

What do systematic reviews say?

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

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No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

Oral gabapentin vs placebo

Change in disability score · adults with SMA types II and III

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 66 participants
Low

Oral gabapentin vs placebo

Muscle strength · adults with SMA types II and III

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Oral antibiotics vs placebo

Withdrawals due to adverse events · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 199 participants
Very low

Oral antibiotics vs placebo

Minor adverse events not leading to withdrawal of treatment · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 68 participants
Very low

Oral antibiotics vs placebo

Microbiology Emergence of resistant organisms · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 98 participants
Very low

Oral antibiotics vs placebo

Global change in composite ratings scale EASI ranges from 0 to 72 with higher values indicating greater severity. · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 68 participants
Moderate

Oral antibiotics vs placebo

No of participants in whom S. aureus was isolated · people with atopic dermatitis

Oral antibiotic showed no clear difference in no of participants in whom S. aureus was isolated compared with placebo (low certainty).

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
RR 0.76 [0.46, 1.26]
3 studies · 144 participants
Low

Oral antibiotics vs placebo

Global outcome (good or excellent improvement in symptoms or signs, or both) · people with atopic dermatitis

Oral antibiotic showed no clear difference in global outcome (good or excellent improvement in symptoms or signs,… compared with placebo (low certainty).

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
RR 0.8 [0.18, 3.5]
2 studies · 75 participants
Low

Oral antibiotics vs placebo

Change from baseline in quality of life IDQoL ranges from 0 to 30 with higher values indicating more impaired quality of life. · people with atopic dermatitis

1 finding from 1 review

Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 45 participants
Moderate

Oral gentamicin vs nalidixic acid

Diarrhoea · patients with Shigella dysentery

It is very uncertain whether oral gentamicin changes diarrhoea at compared with nalidixic acid (very low certainty).

1 finding from 1 review

Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
RR 1.71 [0.98, 2.97]
1 study · 79 participants
Very low

Oral gentamicin vs nalidixic acid

Relapse ‐ not reported · patients with Shigella dysentery

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral gentamicin vs nalidixic acid

Serious adverse events ‐ not reported · patients with Shigella dysentery

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral gentamicin vs nalidixic acid

Other adverse events ‐ not reported · patients with Shigella dysentery

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Receipt of treatment for hypoglycaemia during initial hospital stay (investigator‐defined, any treatment ‐ oral dextrose gel, intravenous dextrose, or other drug therapy) during initial hospital stay (yes/no) · newborn infants at risk of neonatal hypoglycaemia

Dextrose gel showed no clear difference in receipt of treatment for hypoglycaemia during initial hospital stay… compared with placebo (moderate certainty).

1 finding from 1 review

Oral dextrose gel to prevent hypoglycaemia in at‐risk neonates 2023 · Cochrane Headline outcomes only
RR 0.89 [0.79, 1]
2 studies · 2548 participants
Moderate

Oral misoprostol vs vaginal misoprostol

Failure to achieve complete abortion · women undergoing first trimester abortion

Oral misoprostol probably leads to higher failure to achieve complete abortion compared with vaginal misoprostol (moderate certainty).

2 findings from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 2.38 [1.46, 3.87]
3 studies · 1704 participants
Moderate
Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 3.68 [1.56, 8.71]
2 studies · 216 participants
Low

Oral misoprostol vs vaginal misoprostol

Nausea · women undergoing first trimester abortion

Oral misoprostol may leads to higher nausea compared with vaginal misoprostol (low certainty).

2 findings from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.14 [1.03, 1.26]
2 studies · 1380 participants
Low
Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.21 [0.92, 1.61]
2 studies · 216 participants
Low

Oral misoprostol vs vaginal misoprostol

Women's dissatisfaction with the procedure · women undergoing first trimester abortion

The review found no eligible studies for this question.

2 findings from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
RR 1.25 [0.65, 2.39]
1 study · 100 participants
Low

Oral misoprostol vs vaginal misoprostol

Blood transfusion · women undergoing first trimester abortion

The review found no eligible studies for this question.

2 findings from 1 review

Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Medical methods for first trimester abortion 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral chloroquine vs placebo

Complete response · patients with cutaneous disease in systemic lupus erythematosus

Oral chloroquine showed no clear difference in primary outcome: complete clinical response compared with placebo (low certainty).

1 finding from 1 review

Interventions for cutaneous disease in systemic lupus erythematosus 2021 · Cochrane Headline outcomes only
RR 1.57 [0.95, 2.61]
1 study · 24 participants
Low

Oral chloroquine vs placebo

Primary outcome: partial clinical response · patients with cutaneous disease in systemic lupus erythematosus

1 finding from 1 review

Interventions for cutaneous disease in systemic lupus erythematosus 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported