Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,661 questions · 2,751 findings · 453 reviews

No studies found 593 · 21.6%GRADE not reported 277 · 10.1%Very low 538 · 19.6%Low 712 · 25.9%Moderate 516 · 18.8%High 115 · 4.2%

Oral hygiene interventions (mechanical plaque removal): knowledge-based, behavioural, or skills training for people with ID or their carers vs Usual care, no care, or a similar alternative intervention

Quality of life changes or long-term, patient-centred outcomes (e.g. tooth retention) · People with intellectual disabilities (ID), living at home, in day care, in hospital or in a residential care setting; all levels of ID as…

The review found no eligible studies for this question.

1 finding from 1 review

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

Long-term skeletal relapse/stability (horizontal movement of A-point) · Adolescents or adults (15 years or older) with an established diagnosis of complete cleft lip and alveolar process, or complete unilateral…

It is very uncertain whether maxillary distraction osteogenesis changes long-term skeletal relapse/stability (horizontal movement of A-point) compared with orthognathic surgery (conventional Le Fort I osteotomy) (very low certainty).

1 finding from 1 review

Cessation interventions with a partner support component vs cessation interventions without a partner support component

Long‐term smoking abstinence (6 to 9 months) · people who smoked and were willing to be recruited to a cessation programme

Cessation interventions with a partner support component showed no clear difference in long‐term smoking abstinence (6 to 9 months) compared with cessation interventions without a partner support component (low certainty).

1 finding from 1 review

Cessation interventions with a partner support component vs cessation interventions without a partner support component

Long‐term smoking abstinence (12 months+) · people who smoked and were willing to be recruited to a cessation programme

Cessation interventions with a partner support component showed no clear difference in long‐term smoking abstinence (12 months+) compared with cessation interventions without a partner support component (low certainty).

1 finding from 1 review

Intervention not reported

Prolonged gestation > 42 weeks · pregnant women

The intervention probably leads to higher prolonged gestation > 42 weeks (moderate certainty).

1 finding from 1 review

Exercise vs no exercise

Adherence · rheumatoid arthritis of the hand

Exercise showed no clear difference in participant adherence ‐ long term (12 months and beyond) compared with no exercise (moderate certainty).

1 finding from 1 review

Exercise vs no exercise

Hand function ‐ long term (12 months and beyond) Overall hand function subscale of the Michigan Hand Questionnaire, 0 to 100 (higher scores mean better hand function) · rheumatoid arthritis of the hand
1 finding from 1 review

Exercise vs no exercise

Pain ‐ long term (12 months and beyond) Pain subscale of Michigan Hand Outcomes Questionnaire (0 to 100 points, higher score means more pain) · rheumatoid arthritis of the hand
1 finding from 1 review

Alpha2‐adrenergic agonist vs control

Acute stroke (within 30‐days after surgery: new focal neurologic deficit with signs and symptoms lasting longer than 24 hours) · adults undergoing cardiac surgery

Alpha‐2 adrenergic agonists may leads to lower acute stroke (within 30‐days after surgery: new focal neurologic… compared with control (low certainty).

1 finding from 1 review

FLUPHENAZINE (ORAL) vs placebo

Adverse effects: Death ‐ long termOccurrences of death · patients with schizophrenia

ORAL FLUPHENAZINE showed no clear difference in adverse effects: Death ‐ long termOccurrences of death compared with PLACEBO (low certainty).

1 finding from 1 review

Oral propranolol vs topical timolol

Adverse events experienced at short or long term ‐ general adverse events 24 weeks' · infantile haemangiomas (strawberry birthmarks) of the skin

It is very uncertain whether oral propranolol changes adverse events experienced at short or long term ‐ general adverse… compared with topical timolol (very low certainty).

1 finding from 1 review