Cochrane · systematic review · CD006545
Interventions for infantile haemangiomas of the skin
Novoa, M, Baselga, E, Beltran, S, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SkinAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
7
No studies
14
Included studies
NR
No studies 14 · 66.7%Ungraded 0 · 0%Very low 1 · 4.8%Low 4 · 19%Moderate 2 · 9.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Oral propranolol compared to placebo for infantile haemangiomas of the skin
Population: infantile haemangiomas (strawberry birthmarks) of the skin
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clearance, as assessed by a clinician at any Oral propranolol vs placebo | RR 16.61 [4.22, 65.34] | 1 study · 156 participants | Moderate Downgraded: imprecision |
A subjective measure of improvement, as assessed by the parent or child, at any Oral propranolol vs placebo | no estimate extracted | NR | No studies |
Adverse events experienced at short or long term ‐ Serious adverse events 24 weeks' Oral propranolol vs placebo | RR 1.05 [0.33, 3.39] | 3 studies · 509 participants | Low Downgraded: imprecision |
Other measures of resolution, as assessed by a clinician, at any Oral propranolol vs placebo | MD 45.9 | 1 study · 40 participants | Moderate Downgraded: risk of bias |
Proportion of parents who consider their child still has a problem, at any Oral propranolol vs placebo | no estimate extracted | NR | No studies |
Proportion of children who consider they still have a problem, at any Oral propranolol vs placebo | no estimate extracted | NR | No studies |
Aesthetic appearance as assessed by physician, child, or parent, at any Oral propranolol vs placebo | no estimate extracted | NR | No studies |
Topical timolol compared to placebo for infantile haemangiomas of the skin
Population: infantile haemangiomas (strawberry birthmarks) of the skin
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clearance, as assessed by a clinician at any Topical timolol vs placebo | no estimate extracted | NR | No studies |
A subjective measure of improvement, as assessed by the parent or child, at any Topical timolol vs placebo | no estimate extracted | NR | No studies |
Adverse events experienced at short or long term ‐ Serious cardiovascular adverse events ‐ bradycardia 24 weeks' Topical timolol vs placebo | no estimate extracted | 1 study · 41 participants | Low Downgraded: imprecision |
Other measures of resolution, as assessed by a clinician, at any Topical timolol vs placebo | RR 8.11 [1.09, 60.09] | 1 study · 41 participants | Low Downgraded: imprecision |
Proportion of parents who consider their child still has a problem, at any Topical timolol vs placebo | no estimate extracted | NR | No studies |
Proportion of children who consider they still have a problem, at any Topical timolol vs placebo | no estimate extracted | NR | No studies |
Aesthetic appearance as assessed by physician, child, or parent, at any Topical timolol vs placebo | no estimate extracted | NR | No studies |
Oral propranolol compared to topical timolol for infantile haemangiomas of the skin
Population: infantile haemangiomas (strawberry birthmarks) of the skin
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clearance, as assessed by a clinician at any Oral propranolol vs topical timolol | no estimate extracted | NR | No studies |
A subjective measure of improvement, as assessed by the parent or child, at any Oral propranolol vs topical timolol | no estimate extracted | NR | No studies |
Adverse events experienced at short or long term ‐ general adverse events 24 weeks' Oral propranolol vs topical timolol | RR 7 [0.4, 123.35] | 1 study · 26 participants | Very low Downgraded: risk of bias, imprecision |
Other measures of resolution, as assessed by a clinician, at any Oral propranolol vs topical timolol | RR 1.13 [0.64, 1.97] | 1 study · 26 participants | Low Downgraded: risk of bias, imprecision |
Proportion of parents who consider their child still has a problem, at any Oral propranolol vs topical timolol | no estimate extracted | NR | No studies |
Proportion of children who consider they still have a problem, at any Oral propranolol vs topical timolol | no estimate extracted | NR | No studies |
Aesthetic appearance as assessed by physician, child, or parent, at any Oral propranolol vs topical timolol | no estimate extracted | NR | No studies |