Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,234 questions · 3,357 findings · 396 reviews

No studies found 803 · 23.9%GRADE not reported 270 · 8%Very low 757 · 22.5%Low 859 · 25.6%Moderate 486 · 14.5%High 182 · 5.4%

Preoperative paracetamol (acetaminophen) vs placebo

Postoperative pain (dichotomous measure: parent report of presence of pain-related behaviours) · Children and adolescents having dental treatment under local anaesthetic (restorative and extraction treatments)

Preoperative paracetamol (acetaminophen) showed no clear difference in postoperative pain (dichotomous measure: parent report of presence… compared with placebo (low certainty).

1 finding from 1 review

Summary of findings: bilateral laminotomy vs conventional laminectomy

Incidence of postoperative instability · patients with lumbar stenosis

Summary of findings: bilateral laminotomy may leads to lower incidence of postoperative instability compared with conventional laminectomy (low certainty).

1 finding from 1 review

Summary of findings: bilateral laminotomy vs conventional laminectomy

Incidence of perioperative complications · patients with lumbar stenosis

Summary of findings: bilateral laminotomy showed no clear difference in incidence of perioperative complications compared with conventional laminectomy (low certainty).

1 finding from 1 review

Tramadol in combination with acetaminophen vs placebo

Number of participants reporting an adverse event · patients with osteoarthritis

Tramadol in combination with acetaminophen probably leads to higher number of participants experiencing any adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol in combination with acetaminophen vs placebo

Withdrawals due to adverse events · patients with osteoarthritis

Tramadol in combination with acetaminophen may leads to higher number of participants who withdrew due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Tramadol in combination with acetaminophen vs NSAIDs

Number of participants reporting an adverse event · patients with osteoarthritis

Tramadol in combination with acetaminophen showed no clear difference in number of participants experiencing any adverse event compared with NSAIDs (low certainty).

1 finding from 1 review