Search review questions

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Holgerson,2009 [32]; model performance 1

Caries prevention (preventive fraction, SDF vs GIC+5% fluoride varnish) · intellectually disabled individuals with caries in permanent posterior teeth · 6 months

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Beck,1992 [24]; model performance 7

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 4

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Fontana,2011 [16]; model performance 8

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Beck,1992 [24]; model performance 4

Pulp necrosis · Vital teeth restored with indirect restorations · Follow-up ≤5 to >10 years, Treated by general practitioners

Pulp necrosis · Vital teeth restored with indirect restorations · Follow-up ≤5 to >10 years, Single-unit restorations

Root caries increment · Individuals of all ages · Follow-up ≥1 year, Hayes,2017 [33]; model performance 1

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Demers,1992 [14]; model performance 2

CA VI activity · Participants with dental caries and caries-free participants

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Gao,2013 [29]; model performance 10

new root-surface carious lesions or restorations · community-dwelling older adults with root caries · 24 months

MMP-2 location/presence · Human carious dentin

Locoregional recurrence · Adults with oropharyngeal cancer

MMP-9 expression/activity · Human carious dentin · 60 days after cavity sealing

Recurrence · Adults with oral cavity or oropharyngeal cancer

Drooling Severity and Frequency Scale (DSFS) score · Adults with Parkinson's disease and sialorrhea (drooling) · Approximately 1 month post-injection (one study ~1 week), BoNT type B

Oral health-related quality of life (dichotomous: poor vs not) · Indian children, adolescents and adults

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 10

Prevalence of white spot lesions (WSL) at debonding, subject level · Healthy adolescents and adults undergoing orthodontic treatment with fixed multi-bracket appliances · At debonding

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Disney,1992 [15]; model performance 3

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Dolic,2020 [28]; model performance 2

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Pang,2021 [19]; model performance 3

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 1

Pulp necrosis incidence · Vital teeth · General practitioners

Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)

Pulp necrosis incidence · Vital teeth · Eugenol-free

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Gao,2013 [29]; model performance 4

Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)

Oral health-related quality of life (dichotomous: poor vs not) · Indian elderly and general-population adults

Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Fontana,2011 [16]; model performance 10

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 2

Severity of white spot lesions (surface area and depth) · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries) · Baseline to end of treatment (varying)

Secondary caries (occurrence) · Patients requiring dental restoration; permanent teeth · 2 or more years of follow-up

Oral health-related quality of life (continuous), measured by OHIP-14 · Indian elderly

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Dolic,2020 [28]; model performance 1

Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)

Oral health-related quality of life · Adolescents aged 10-19 years

Poor oral health-related quality of life · Indians

Bacterial collagenolytic protease gene expression · Human ex vivo carious lesions / caries-associated biofilm

Root caries increment · Individuals of all ages · Follow-up ≥1 year, Ritter,2016 [22]; model performance 3

Salivary/biofilm CA VI (carbonic anhydrase VI) activity · Children (age about 2-9 years) across the 7 meta-analyzed activity samples; excludes Kivela 1999 adults (18-24 years),… · Cross-sectional (single time point)

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Beck,1992 [24]; model performance 7

Adverse events (participants with >=1 adverse event) · Adults with Parkinson's disease and sialorrhea (drooling) · Approximately 1 month post-injection (one study ~1 week), BoNT type A

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 5

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Gao,2013 [29]; model performance 7

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Gao,2013 [29]; model performance 12

restoration and caries status · children with caries in permanent molars · 9 months