Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Bioengineered devices vs standard techniques

Specific serious adverse events: further surgery (device removal or revision)i assessed as: any unplanned secondary surgery to remove device · people undergoing peripheral nerve repair of the upper limb

It is very uncertain whether bioengineered devices changes specific serious adverse events: further surgery (device removal or… compared with standard techniques (very low certainty).

1 finding from 1 review

Immediate vs delayed postabortion insertion of contraceptive implants

Failure rate of medical abortion—require surgery for complete abortion at · women who experienced abortions and requested a reversible contraceptive method

Immediate showed no clear difference in failure rate of medical abortion—require surgery for complete… compared with delayed postabortion insertion of contraceptive implants (moderate certainty).

1 finding from 1 review

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Any death postsurgery Time point: 6 years to 9 years from randomisation · healthy adults

Low‐dose computed tomography (LDCT) screening showed no clear difference in any death postsurgery Time point: 6 years to 9 years from… compared with no LDCT screening (moderate certainty).

1 finding from 1 review

Endometrial resection or ablation vs minimally invasive hysterectomy

Requirement for further surgery for treatment failure within 1 year after surgery · heavy menstrual bleeding

Endometrial resection or ablation probably leads to higher requirement for further surgery for treatment failure within 1 year… compared with minimally invasive hysterectomy (moderate certainty).

1 finding from 1 review

Patching vs active observation

Stereoacuity at distance Loss of ≥ 2 octaves near stereoacuity Measured using the Preschool Randot test 3 years after surgery · people with intermittent exotropia, aged less than 11 years

The review found no eligible studies for this question.

1 finding from 1 review

Patching vs active observation

Minor adverse events Defined as any adverse event within 8 weeks of surgery that does not require further intervention · people with intermittent exotropia, aged less than 11 years

The review found no eligible studies for this question.

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Stereoacuity at near Loss of ≥ 2 octaves near stereoacuity, measured using the Preschool Randot test 3 years after surgery · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in stereoacuity at near Loss of ≥ 2 octaves near stereoacuity, measured… compared with unilateral lateral rectus recession with medial rectus resection (low certainty).

1 finding from 1 review

Lateral rectus recession and medial rectus plication vs lateral rectus recession and medial rectus resection

Stereoacuity at distance Loss of ≥ 2 octaves near stereoacuity Measured using the Preschool Randot test 3 years after surgery · people with intermittent exotropia, aged over 6 years

The review found no eligible studies for this question.

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Minor adverse events Defined as any adverse event within 8 weeks of surgery that does not require further intervention · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in minor adverse events Defined as any adverse event within 8 weeks of… compared with unilateral lateral rectus recession with medial rectus resection (low certainty).

1 finding from 1 review

Transurethral microwave thermotherapy vs sham

Retreatment Participants requiring additional procedures or surgery · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Transurethral microwave thermotherapy may leads to lower retreatment Participants requiring additional procedures or surgery compared with sham treatment (low certainty).

1 finding from 1 review

Transurethral microwave thermotherapy vs transurethral resection of the prostate

Retreatment Participants requiring additional procedures or surgery · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Transurethral microwave thermotherapy probably leads to higher retreatment Participants requiring additional procedures or surgery compared with transurethral resection of the prostate (moderate certainty).

1 finding from 1 review