Tricyclic antidepressants vs control
Pain < 1 week VAS scale 0 to 100 mm · patients with pain management in rheumatoid arthritis
1 finding from 1 review
- no estimate extracted1 study · 30 participantsVery low
Findings
What do systematic reviews say?
3,747 questions · 3,943 findings · 594 reviews
No studies found 784 · 19.9%GRADE not reported 530 · 13.4%Very low 1,040 · 26.4%Low 981 · 24.9%Moderate 444 · 11.3%High 164 · 4.2%
Tricyclic antidepressants vs control
Pain 1 to 6 weeks Any pain measurement scale · patients with pain management in rheumatoid arthritis
1 finding from 1 review
- no estimate extracted7 studies · 482 participantsVery low
Tricyclic antidepressants vs control
Pain > 6 weeks Any pain measurement scale · patients with pain management in rheumatoid arthritis
1 finding from 1 review
- no estimate extracted5 studies · 368 participantsVery low
Tricyclic antidepressants vs control
Functional Status Health Assessment Questionnaire (HAQ) scale 0 to 3 · patients with pain management in rheumatoid arthritis
1 finding from 1 review
- no estimate extracted1 study · 28 participantsLow
Tricyclic antidepressants vs control
Withdrawals due to adverse events · patients with pain management in rheumatoid arthritis
It is very uncertain whether tricyclic antidepressant changes number of Withdrawals due to Adverse Events patient interview compared with control (very low certainty).
1 finding from 1 review
- RR 0.98 [0.59, 1.64]6 studies · 455 participantsVery low
Tricyclic antidepressants vs control
Total number of adverse events patient interview · patients with pain management in rheumatoid arthritis
It is very uncertain whether tricyclic antidepressant changes total number of adverse events patient interview compared with control (very low certainty).
1 finding from 1 review
- RR 1.83 [1.01, 3.3]6 studies · 455 participantsVery low
Tricyclic antidepressants vs placebo
Leaving the study early · adults with panic disorder
Tricyclic antidepressants probably leads to lower total number of dropouts compared with placebo (moderate certainty).
1 finding from 1 review
- RR 0.74 [0.63, 0.86]17 studies · 1906 participantsModerate
Tricyclic antidepressants vs placebo
Failure to remit at endpoint · adults with panic disorder
Tricyclic antidepressants may leads to lower failure to remit compared with placebo (low certainty).
1 finding from 1 review
- RR 0.82 [0.69, 0.99]8 studies · 1294 participantsLow
Tricyclic antidepressants vs placebo
panic symptoms · adults with panic disorder
2 findings from 1 review
- no estimate extracted7 studies · 1247 participantsModerate
- no estimate extracted2 studies · 70 participantsVery low
Tricyclic antidepressants vs placebo
Withdrawals due to adverse events · adults with panic disorder
Tricyclic antidepressants probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty).
1 finding from 1 review
- RR 1.97 [1.33, 2.91]10 studies · 1641 participantsModerate
Tricyclic antidepressants vs placebo
Outcomes (2‐6 months post‐treatment) · adults with panic disorder
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Tricyclic antidepressants vs placebo
Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder
Tricyclic antidepressants probably leads to lower failure to respond compared with placebo (moderate certainty).
1 finding from 1 review
- RR 0.73 [0.63, 0.86]9 studies · 829 participantsModerate
Tricyclic antidepressants vs placebo
Quality of sleep · adults with insomnia
1 finding from 1 review
- no estimate extracted4 studies · 518 participantsModerate
Tricyclic antidepressants vs placebo
Adverse events (at 4, 6 or 12 weeks) · adults with insomnia
Tricyclic antidepressants showed no clear difference in adverse events (at 4, 6 or 12 weeks) compared with placebo (low certainty).
1 finding from 1 review
- RR 1.02 [0.86, 1.21]6 studies · 812 participantsLow
Tricyclic antidepressants vs placebo
Sleep onset latency ‐ not reported · adults with insomnia
1 finding from 1 review
- no estimate extracted4 studies · 510 participantsModerate
Tricyclic antidepressants vs placebo
Sleep efficiency · adults with insomnia
1 finding from 1 review
- no estimate extracted4 studies · 510 participantsModerate
Tricyclic antidepressants vs placebo
Total sleep time, next night; · adults with insomnia
1 finding from 1 review
- no estimate extracted4 studies · 510 participantsModerate
Tricyclic antidepressants vs placebo
Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use
It is very uncertain whether tricyclic antidepressants changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).
1 finding from 1 review
- Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users 2018 · Cochrane Headline outcomes onlyRR 0.82 [0.52, 1.28]2 studies · 105 participantsVery low
Tricyclic antidepressants vs placebo
Benzodiazepine discontinuation, longest · adults who withdraw from chronic benzodiazepine use
Tricyclic antidepressants may leads to higher benzodiazepine discontinuation, longest compared with placebo (low certainty).
1 finding from 1 review
- Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users 2018 · Cochrane Headline outcomes onlyRR 2.2 [1.27, 3.82]1 study · 47 participantsLow
Tricyclic antidepressants vs placebo
Benzodiazepine withdrawal symptoms, end of intervention · adults who withdraw from chronic benzodiazepine use
1 finding from 1 review
- Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users 2018 · Cochrane Headline outcomes onlyno estimate extracted1 study · 38 participantsVery low