Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,973 questions · 3,072 findings · 410 reviews · Headline outcomes only

No studies found 559 · 18.2%GRADE not reported 143 · 4.7%Very low 654 · 21.3%Low 833 · 27.1%Moderate 683 · 22.2%High 200 · 6.5%

Summary of findings ‐ ivacaftor vs placebo

Time to first pulmonary exacerbation · adults and children with cystic fibrosis and with at least one R117H CFTR mutation

Summary of findings ‐ ivacaftor showed no clear difference in time to first pulmonary exacerbation compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Pulmonary embolism · Patients hospitalised following acute myocardial infarction

The review found no eligible studies for this question.

1 finding from 1 review

Fondaparinux vs placebo

Symptomatic VTE · people with ST of the leg

Fondaparinux probably leads to lower symptomatic VTE Ventilation‐perfusion scanning, helical computed… compared with placebo (moderate certainty).

1 finding from 1 review

Perioperative alcohol cessation intervention vs treatment

Postoperative complications after perioperative intervention (e.g. wound‐related complications, secondary surgery, cardiopulmonary complications, admission to intensive care) defined by need for treatment · adult surgical patients consuming 3 or more units of alcohol per day

Perioperative alcohol cessation intervention probably leads to lower postoperative complications after perioperative intervention (e.g.… compared with treatment (moderate certainty).

1 finding from 1 review

Percutaneous surgery vs open surgery

Adverse events (infection, partial loss of movement, tendon or pulley injury, oedema or inflammation or hematoma, adherence) · patients with trigger finger

It is very uncertain whether percutaneous surgery changes adverse events (infection, partial loss of movement, tendon or… compared with open surgery (very low certainty).

1 finding from 1 review

Open surgery vs steroid injection

Adverse events (infection, tendon or pulley injury, flare, cutaneous discomfort, fat necrosis) · patients with trigger finger

Open surgery showed no clear difference in adverse events (infection, tendon or pulley injury, flare, cutaneous… compared with steroid injection (low certainty).

1 finding from 1 review