Cochrane · systematic review · CD012300
Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis
Palser, S, Smith, S, Nash, EF, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 1 · 14.3%Low 0 · 0%Moderate 4 · 57.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings: cycled versus culture‐based antibiotic therapy for preventing recurrence of infection with Pseudomonas aeruginosa
Population: children (aged 1 to 12 years) with CF and a newly isolated PA infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to next isolation of PA Summary of findings: cycled vs culture‐based antibiotic therapy | HR 2.04 [1.28, 3.26] | 1 study · 253 participants | Moderate Downgraded: risk of bias, indirectness |
Quality of life Summary of findings: cycled vs culture‐based antibiotic therapy | no estimate extracted | NR | No studies |
FEV1: change from baseline (L) Summary of findings: cycled vs culture‐based antibiotic therapy | no estimate extracted | 1 study · 131 participants | Very low Downgraded: risk of bias, indirectness |
Pulmonary exacerbations: frequency Summary of findings: cycled vs culture‐based antibiotic therapy | no estimate extracted | 1 study · 253 participants | Moderate Downgraded: risk of bias, indirectness |
Time to chronic PA Summary of findings: cycled vs culture‐based antibiotic therapy | no estimate extracted | NR | No studies |
Adverse events: severe adverse events (total) Summary of findings: cycled vs culture‐based antibiotic therapy | RR 0.65 [0.39, 1.11] | 1 study · 253 participants | Moderate Downgraded: risk of bias, indirectness |
Emergence of novel bacteria: isolation of novel gram negative organisms Summary of findings: cycled vs culture‐based antibiotic therapy | RR 1 [0.67, 1.5] | 1 study · 253 participants | Moderate Downgraded: risk of bias, indirectness |