Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,234 questions · 3,357 findings · 396 reviews

No studies found 803 · 23.9%GRADE not reported 270 · 8%Very low 757 · 22.5%Low 859 · 25.6%Moderate 486 · 14.5%High 182 · 5.4%

Acetaminophen plus Diphenhydramine vs placebo

Anaphylatic reactions ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydramine led to lower anaphylatic reactions ‐ not reported compared with placebo; GRADE not reported.

1 finding from 1 review

Acetaminophen plus Diphenhydramine vs placebo

Death ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydramine led to lower death ‐ not reported compared with placebo; GRADE not reported.

1 finding from 1 review

Acetaminophen plus Diphenhydramine vs placebo

Adverse events · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydramine led to lower adverse events compared with placebo; GRADE not reported.

1 finding from 1 review

Acetaminophen plus Diphenhydramine vs placebo

Allergic reactions (urticaria with or without pruritus) ‐ Intention‐to treat analysis · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

It is very uncertain whether acetaminophen plus Diphenhydramine changes allergic reactions (urticaria with or without pruritus) ‐… compared with placebo (very low certainty).

1 finding from 1 review

Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion)

Adverse events · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydrammine led to lower adverse events compared with placebo (Unit of randomisation: transfusion); GRADE not reported.

1 finding from 1 review

Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion)

Fever · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydrammine showed no clear difference in fever ‐ Per protocol analysis compared with placebo (Unit of randomisation: transfusion) (low certainty).

1 finding from 1 review

Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion)

Anaphylatic reactions ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydrammine led to lower anaphylatic reactions ‐ not reported compared with placebo (Unit of randomisation: transfusion); GRADE not reported.

1 finding from 1 review

Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion)

Hives ‐ Per protocol analysis · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydrammine showed no clear difference in hives ‐ Per protocol analysis compared with placebo (Unit of randomisation: transfusion) (low certainty).

1 finding from 1 review

Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion)

Death ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydrammine led to lower death ‐ not reported compared with placebo (Unit of randomisation: transfusion); GRADE not reported.

1 finding from 1 review

Summary of findings: Aminosalicylates vs placebo

Acute and late GI toxicity (grade 2+) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer

Summary of findings: Aminosalicylates probably leads to higher acute and late GI toxicity (grade 2+) compared with placebo (moderate certainty).

1 finding from 1 review