Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,971 questions · 9,849 findings · 853 reviews

No studies found 1,150 · 11.7%GRADE not reported 3,387 · 34.4%Very low 1,963 · 19.9%Low 1,809 · 18.4%Moderate 1,207 · 12.3%High 333 · 3.4%

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Antibiotics vs no treatment or placebo on top of topical antibiotics

Resolution of ear discharge ‐ measured after 4 weeks · people with CSOM; one study included patients of unknown age; one study included children with CSOM who had not responded to initial…

It is very uncertain whether systemic antibiotics changes resolution of ear discharge ‐ measured after 4 weeks (4 weeks)… compared with no treatment or placebo on top of topical antibiotics (very low certainty).

2 findings from 1 review

Intervention not reported

Improvement of nutritional parameters (Nutrition)j · people with severe dementia
1 finding from 1 review

Intervention not reported

Change in metamorphopsia from baseline to 6‐month · People with lamellar macular holes

The review found no eligible studies for this question.

1 finding from 1 review

Rubber dam vs No rubber dam

Reduction in level of contamination in aerosols (CFU) during restorative procedures at 2 metres from mouth (CCT) · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether rubber dam changes reduction in level of contamination in aerosols (CFU) during… compared with no rubber dam (very low certainty).

2 findings from 1 review

Rubber dam vs No rubber dam

Reduction in level of contamination in aerosols (CFU) during restorative procedures at 1 metre from mouth (CCT) · People undergoing aerosol-generating procedures (AGPs) in a dental setting

Rubber dam led to lower reduction in level of contamination in aerosols (CFU) during… compared with no rubber dam; GRADE not reported.

1 finding from 1 review

Radiotherapy vs surgical excision

Cosmetic outcome (good/excellent) · adults with basal cell carcinoma of the skin

Radiotherapy probably leads to lower cosmetic outcome (good/excellent) compared with surgical excision (with or without frozen section margin control) (moderate certainty).

1 finding from 1 review

Imiquimod vs MAL‐PDT

Cosmesis · adults with basal cell carcinoma of the skin

Imiquimod cream showed no clear difference in cosmetic outcome (excellent/good) compared with MAL‐PDT (moderate certainty).

1 finding from 1 review