Cochrane · systematic review · CD003412
Interventions for basal cell carcinoma of the skin
Thomson, J, Hogan, S, Leonardi-Bee, J, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SkinAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
24
current version
GRADE rated
19
No studies
5
Included studies
NR
No studies 5 · 20.8%Ungraded 0 · 0%Very low 0 · 0%Low 9 · 37.5%Moderate 10 · 41.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Mohs micrographic surgery compared to surgical excision for basal cell carcinoma of the skin
Population: adults with basal cell carcinoma of the skin
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Recurrence at 3 years Mohs micrographic surgery vs surgical excision | RR 0.64 [0.16, 2.64] | 1 study · 331 participants | Low Downgraded: imprecision |
Recurrence at 5 years Mohs micrographic surgery vs surgical excision | RR 0.61 [0.18, 2.04] | 1 study · 259 participants | Low Downgraded: imprecision |
Cosmetic outcome Mohs micrographic surgery vs surgical excision | no estimate extracted | 1 study · 1 participants | Low Downgraded: imprecision, indirectness |
Pain Mohs micrographic surgery vs surgical excision | no estimate extracted | NR | No studies |
Early treatment failure Mohs micrographic surgery vs surgical excision | no estimate extracted | NR | No studies |
Imiquimod compared to surgical excision for basal cell carcinoma of the skin
Population: adults with basal cell carcinoma of the skin
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Recurrence at 3 years Imiquimod vs surgical excision | RR 10.3 [3.22, 32.94] | 1 study · 401 participants | Moderate Downgraded: imprecision |
Recurrence at 5 years Imiquimod vs surgical excision | RR 7.73 [2.81, 21.3] | 1 study · 383 participants | Moderate Downgraded: imprecision |
Cosmetic outcome (good/excellent) Imiquimod vs surgical excision | RR 1.7 [1.35, 2.15] | 1 study · 344 participants | Low Downgraded: risk of bias, imprecision |
Pain (moderate/severe) Imiquimod vs surgical excision | RR 1.36 [0.98, 1.88] | 1 study · 443 participants | Low Downgraded: risk of bias, imprecision |
Early treatment failure Imiquimod vs surgical excision | no estimate extracted | NR | No studies |
Radiotherapy compared to surgical excision (with or without frozen section margin control) for basal cell carcinoma of the skin
Population: adults with basal cell carcinoma of the skin
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Recurrence at 3 years Radiotherapy vs surgical excision (with or without frozen section margin control) | RR 19.11 [1.12, 325.78] | 1 study · 347 participants | Low Downgraded: imprecision |
Recurrence at 4 years Radiotherapy vs surgical excision (with or without frozen section margin control) | RR 11.06 [1.44, 84.77] | 1 study · 347 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Cosmetic outcome (good/excellent) Radiotherapy vs surgical excision (with or without frozen section margin control) | RR 0.76 [0.63, 0.91] | 1 study · 347 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Pain Radiotherapy vs surgical excision (with or without frozen section margin control) | no estimate extracted | NR | No studies |
Early treatment failure Radiotherapy vs surgical excision (with or without frozen section margin control) | no estimate extracted | NR | No studies |
MAL‐PDT compared to surgical excision for basal cell carcinoma of the skin
Population: adults with basal cell carcinoma of the skin
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Recurrence at 3 years MAL‐PDT vs surgical excision | RR 26.47 [1.63, 429.92] | 1 study · 68 participants | Low Downgraded: imprecision |
Cosmetic outcome (excellent/good) MAL‐PDT vs surgical excision | RR 1.18 [1.09, 1.27] | 2 studies · 309 participants | Moderate Downgraded: risk of bias, imprecision |
Pain MAL‐PDT vs surgical excision | RR 2.2 [0.6, 8.03] | 1 study · 101 participants | Low Downgraded: risk of bias, imprecision |
Early treatment failure MAL‐PDT vs surgical excision | RR 6.66 [1.22, 36.41] | 2 studies · 173 participants | Moderate Downgraded: risk of bias, imprecision |
Imiquimod cream compared to MAL‐PDT for basal cell carcinoma of the skin
Population: adults with basal cell carcinoma of the skin
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Recurrence at 3 years Imiquimod cream vs MAL‐PDT | RR 0.44 [0.32, 0.62] | 1 study · 277 participants | Moderate Downgraded: imprecision |
Recurrence at 5 years Imiquimod cream vs MAL‐PDT | RR 0.42 [0.31, 0.57] | 1 study · 228 participants | Moderate Downgraded: imprecision |
Cosmetic outcome (excellent/good) Imiquimod cream vs MAL‐PDT | RR 0.98 [0.84, 1.16] | 1 study · 370 participants | Moderate Downgraded: imprecision |
Pain (moderate/severe) Imiquimod cream vs MAL‐PDT | RR 0.6 [0.41, 0.87] | 1 study · 371 participants | Moderate Downgraded: imprecision |
Early treatment failure Imiquimod cream vs MAL‐PDT | RR 0.64 [0.37, 1.09] | 1 study · 385 participants | Moderate Downgraded: imprecision |