Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,640 questions · 2,709 findings · 446 reviews

No studies found 593 · 21.9%GRADE not reported 241 · 8.9%Very low 538 · 19.9%Low 706 · 26.1%Moderate 516 · 19%High 115 · 4.2%

Secukinumab vs placebo

Proportion of participants without relapse in the long term ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Supine midline head position vs any other supine head position

Long‐term neurodevelopmental outcome ‒not reported · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

The review found no eligible studies for this question.

1 finding from 1 review

Behavioural activation vs any comparator

Treatment efficacy for depression (long term: 24 months) · depression in adults with non‐communicable diseases

Behavioural activation showed no clear difference in treatment efficacy for depression (long term: 24 months) compared with any comparator (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality at longest · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…

It is very uncertain whether the intervention changes mortality at longest (very low certainty).

1 finding from 1 review

Any antimicrobial mouthwash and/or nasal spray (alone or in combination), at any concentration, delivered to healthcare workers, with or without the same intervention given to the patients with COVID-19 vs No treatment or saline or water

Other adverse events (allergy, irritation/burning of nasal, oral or oropharyngeal mucosa, long-term staining of mucous membranes or teeth, accidental ingestion) · Healthcare workers (HCWs) treating patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

Scheduled dental recall intervals (1-, 3- or 6-monthly; oral hygiene instruction with or without scale and polish) plus daily supervised toothbrushing by carers vs usual care

Calculus · Adults (mean age 30.9 years), level of ID unclear; setting day centre

Scheduled dental recall intervals (1-, 3- or 6-monthly; oral hygiene… may leads to lower calculus (long term) compared with usual care (no specific treatment) (low certainty).

1 finding from 1 review

Scheduled dental recall intervals (1-, 3- or 6-monthly; oral hygiene instruction with or without scale and polish) plus daily supervised toothbrushing by carers vs usual care

Gingival pocketing (long term) · Adults (mean age 30.9 years), level of ID unclear; setting day centre

Scheduled dental recall intervals (1-, 3- or 6-monthly; oral hygiene… may leads to lower gingival pocketing (long term) compared with usual care (no specific treatment) (low certainty).

1 finding from 1 review

Scheduled dental recall intervals (1-, 3- or 6-monthly; oral hygiene instruction with or without scale and polish) plus daily supervised toothbrushing by carers vs usual care

Plaque · Adults (mean age 30.9 years), level of ID unclear; setting day centre

Scheduled dental recall intervals (1-, 3- or 6-monthly; oral hygiene… may leads to lower plaque (long term) compared with usual care (no specific treatment) (low certainty).

1 finding from 1 review

Scheduled dental recall intervals (1-, 3- or 6-monthly; oral hygiene instruction with or without scale and polish) plus daily supervised toothbrushing by carers vs usual care

Gingival bleeding (various bleeding indices) · Adults (mean age 30.9 years), level of ID unclear; setting day centre

Scheduled dental recall intervals (1-, 3- or 6-monthly; oral hygiene… showed no clear difference in gingival bleeding (long term) compared with usual care (no specific treatment) (low certainty).

1 finding from 1 review

Oral hygiene training (toothbrushing routine) of people with ID vs No oral hygiene training of people with ID

Behaviour, attitude and self-efficacy (toothbrushing behaviour) (medium and long term) · Children and adults with mild to profound ID; setting residential or school
1 finding from 1 review
  • Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes
    Long term (>12 months)
    Behaviour, attitude and self-efficacy (steps achieved in a toothbrushing routine), 100 days to 19 months; 59 participants (4 NRS); Very Low. Results not in a format for meta-analysis: 3 NRS (56 participants) reported…
    4 studies · 59 participants
    Very low