Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,971 questions · 9,849 findings · 853 reviews

No studies found 1,150 · 11.7%GRADE not reported 3,387 · 34.4%Very low 1,963 · 19.9%Low 1,809 · 18.4%Moderate 1,207 · 12.3%High 333 · 3.4%

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Dexrazoxane vs no cardioprotective intervention

Tumour response rate Defined as number of complete responses (i.e. disappearance of active Hodgkin lymphoma (gallium negative, ≥ 70% decrease in the sum of the products of the perpendicular diameters of measurable lesions, and negative bone marrow... · children with cancer receiving anthracyclines

Dexrazoxane showed no clear difference in tumour response rate Defined as number of complete responses (i.e.… compared with no cardioprotective intervention (low certainty).

1 finding from 1 review

Visual or visual-tactile classification systems (any system: ICDAS, ERK, Nyvad, Downer, Lussi, UniViSS, or unspecified) vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)

Diagnostic accuracy (sensitivity/specificity) for enamel caries, not meta-analyzed · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Foam sclerotherapy vs foam sclerotherapy

Cosmetic appearance · participants with varicose veinsa

It is very uncertain whether foam sclerotherapy changes cosmetic appearance (self‐described cosmetic improvement) compared with foam sclerotherapy (very low certainty).

1 finding from 1 review

Intervention not reported

Case‐only ecological method ‐ Urabe · children 9 months to 15 years old

The intervention may leads to higher case‐only ecological method ‐ Urabe (low certainty).

1 finding from 1 review

Intervention not reported

Case‐only ecological method ‐ Leningrad‐Zagreb · children 9 months to 15 years old

The intervention may leads to higher case‐only ecological method ‐ Leningrad‐Zagreb (low certainty).

1 finding from 1 review

Recombinant human growth hormone vs placebo or no intervention

Measures of mineral metabolism: change in serum phosphate mmol/L · children with X‐linked hypophosphataemia

It is very uncertain whether summary of findings ‐ recombinant growth hormone changes measures of mineral metabolism: change in serum phosphate mmol/L compared with placebo or no intervention (very low certainty).

1 finding from 1 review

RGD peptide matrix vs placebo

Complete closureUlcer area was determined by computerized planimetry · individuals with sickle cell disease and a leg ulcer

It is very uncertain whether RGD peptide matrix changes complete closureUlcer area was determined by computerized planimetry compared with placebo (very low certainty).

1 finding from 1 review

Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes

Endometritis · women undergoing caesarean section

Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) showed no clear difference in maternal endometritis compared with broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all… (low certainty).

1 finding from 1 review