Cochrane · systematic review · CD007077
Partial breast irradiation versus whole breast radiotherapy for early breast cancer
Hickey, BE, Lehman, M · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 5 · 71.4%High 2 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 3 versionsSummary of Findings Table ‐ PBI?APBI compared to WBRT for early breast cancer
Population: health problem or population
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Local recurrence‐free survival ‐ total (LR‐FS) Summary of Findings Table ‐ PBI?APBI vs WBRT | HR 1.21 [1.03, 1.42] | 8 studies · 13168 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Cosmesis, physician/nurse‐reported Summary of Findings Table ‐ PBI?APBI vs WBRT | OR 1.57 [1.31, 1.87] | 6 studies · 3652 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Overall survival Summary of Findings Table ‐ PBI?APBI vs WBRT | HR 0.99 [0.88, 1.12] | 8 studies · 13175 participants | High |
Subcutaneous fibrosis (late RT toxicity) Summary of Findings Table ‐ PBI?APBI vs WBRT | OR 5.07 [3.81, 6.74] | 2 studies · 3011 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Cause‐specific survival (C‐SS) Summary of Findings Table ‐ PBI?APBI vs WBRT | HR 1.06 [0.83, 1.36] | 7 studies · 9865 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Distant metastasis‐free survival (DM‐FS) Summary of Findings Table ‐ PBI?APBI vs WBRT | HR 0.95 [0.8, 1.13] | 7 studies · 11033 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Subsequent mastectomy Summary of Findings Table ‐ PBI?APBI vs WBRT | OR 0.98 [0.78, 1.23] | 3 studies · 3740 participants | High |