Cochrane · systematic review · CD007077
Partial breast irradiation versus whole breast radiotherapy for early breast cancer
Hickey, BE, Lehman, M · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 5 · 71.4%High 2 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySummary of Findings Table ‐ PBI?APBI compared to WBRT for early breast cancer
Population: health problem or population
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Local recurrence‐free survival ‐ total (LR‐FS) Summary of Findings Table ‐ PBI?APBI vs WBRT | HR 1.21 [1.03, 1.42] | 8 studies · 13168 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Cosmesis, physician/nurse‐reported Summary of Findings Table ‐ PBI?APBI vs WBRT | OR 1.57 [1.31, 1.87] | 6 studies · 3652 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Overall survival Summary of Findings Table ‐ PBI?APBI vs WBRT | HR 0.99 [0.88, 1.12] | 8 studies · 13175 participants | High |
Subcutaneous fibrosis (late RT toxicity) Summary of Findings Table ‐ PBI?APBI vs WBRT | OR 5.07 [3.81, 6.74] | 2 studies · 3011 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Cause‐specific survival (C‐SS) Summary of Findings Table ‐ PBI?APBI vs WBRT | HR 1.06 [0.83, 1.36] | 7 studies · 9865 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Distant metastasis‐free survival (DM‐FS) Summary of Findings Table ‐ PBI?APBI vs WBRT | HR 0.95 [0.8, 1.13] | 7 studies · 11033 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Subsequent mastectomy Summary of Findings Table ‐ PBI?APBI vs WBRT | OR 0.98 [0.78, 1.23] | 3 studies · 3740 participants | High |
Partial breast irradiation (PBI)/accelerated partial breast irradiation (APBI) for early breast cancer
Population: women with early breast cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Local recurrence‐free survival at 5 years | HR 1.62 [1.11, 2.35] | 6 studies · 6820 participants | Low Downgraded: risk of bias, inconsistency |
Cosmesis | OR 1.51 [1.17, 1.95] | 5 studies · 1720 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Late radiotherapy toxicity (subcutaneous fibrosis) | OR 6.58 [3.08, 14.06] | 1 study · 766 participants | Moderate Downgraded: imprecision, inconsistency |
Cause‐specific survival at 5 years | HR 1.08 [0.73, 1.58] | 5 studies · 6718 participants | Moderate |
Distant metastasis‐free survival at 5 years | HR 0.94 [0.65, 1.37] | 4 studies · 3267 participants | Moderate |
Mastectomy rate | OR 1.2 [0.77, 1.87] | 3 studies · 4817 participants | Low |
Mortality ( | HR 0.9 [0.74, 1.09] | 5 studies · 6718 participants | High |
Partial breast irradiation or accelerated partial breast irradiation for early breast cancer
Population: patients with early breast cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Local recurrence‐free survival Determined using mammography and clinical examination1 | HR 1.74 [1.23, 2.45] | 3 studies · 1140 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Cosmesis Global cosmetic score5 | OR 0.4 [0.23, 0.72] | 1 study · 241 participants | Very low Downgraded: imprecision |
Overall survival | HR 0.99 [0.83, 1.18] | 3 studies · 1140 participants | Very low Downgraded: risk of bias, indirectness |
Late toxicity ‐ Subcutaneous breast fibrosis Unvalidated three point scale | OR 4.27 [3.04, 6.01] | 1 study · 710 participants | Very low Downgraded: imprecision |
Subsequent mastectomy | OR 0.2 [0.01, 4.21] | 1 study · 258 participants | Very low Downgraded: imprecision |
Cause‐specific survival | HR 0.95 [0.74, 1.22] | 2 studies · 966 participants | Low Downgraded: risk of bias |
Distant metastasis‐free survival | HR 1.02 [0.81, 1.28] | 3 studies · 1140 participants | Low Downgraded: risk of bias, indirectness |