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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

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Review versions

1,554 questions in 140 reviews · Heart

current versions

No studies 272 · 17.5%Ungraded 44 · 2.8%Very low 329 · 21.2%Low 464 · 29.9%Moderate 319 · 20.5%High 126 · 8.1%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
Pre‐hospital vs in‐hospital thrombolysis Adverse effects ‐ bleeding complications · participants with ST‐elevation myocardial infarction Pre‐hospital versus in‐hospital thrombolysis for ST‐elevation myocardial infarction (2014) · Cochrane	RR 0.88 [0.41, 1.92]	2 studies · 438 participants	Moderate
Pre‐hospital vs in‐hospital thrombolysis Adverse effects ‐ allergic reaction · participants with ST‐elevation myocardial infarction Pre‐hospital versus in‐hospital thrombolysis for ST‐elevation myocardial infarction (2014) · Cochrane	RR 0 [0.19, 77.03]	1 study · 100 participants	Low
Pre‐hospital vs in‐hospital thrombolysis Adverse effects ‐ Stroke · participants with ST‐elevation myocardial infarction Pre‐hospital versus in‐hospital thrombolysis for ST‐elevation myocardial infarction (2014) · Cochrane	RR 2.11 [0.39, 11.4]	1 study · 360 participants	Low
Intervention NR Recurrent pericarditis Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Intervention: colchicine with NSAID; Comparison: NSAID alone Colchicine for pericarditis (2014) · Cochrane	HR 0.37 [0.24, 0.58]	2 studies · 204 participants	Moderate
Intervention NR months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Colchicine for pericarditis (2014) · Cochrane	RR 0.41 [0.28, 0.61]	2 studies · 360 participants	Moderate
Intervention NR Symptom relief at 72 hours Patient reported Colchicine for pericarditis (2014) · Cochrane	RR 1.4 [1.26, 1.56]	4 studies · 564 participants	Low
Intervention NR Acute pericarditis Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Intervention: colchicine with NSAID; Comparison: NSAID alone Colchicine for pericarditis (2014) · Cochrane	HR 0.4 [0.27, 0.61]	2 studies · 360 participants	Moderate
Intervention NR Total adverse effects Patient reported Colchicine for pericarditis (2014) · Cochrane	RR 1.26 [0.75, 2.12]	4 studies · 564 participants	Low
Intervention NR Adverse effects necessitating stop of therapy Patient reported Colchicine for pericarditis (2014) · Cochrane	RR 1.87 [1.02, 3.41]	4 studies · 564 participants	Moderate
Intervention NR months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Colchicine for pericarditis (2014) · Cochrane	RR 0.28 [0.17, 0.47]	2 studies · 204 participants	Moderate
Intervention NR months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Colchicine for pericarditis (2014) · Cochrane	RR 0.36 [0.23, 0.56]	2 studies · 204 participants	Moderate
Intervention NR months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Colchicine for pericarditis (2014) · Cochrane	RR 0.38 [0.25, 0.58]	2 studies · 204 participants	Moderate
Intervention NR months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Colchicine for pericarditis (2014) · Cochrane	RR 0.36 [0.23, 0.58]	2 studies · 360 participants	Moderate
Intervention NR months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Colchicine for pericarditis (2014) · Cochrane	RR 0.4 [0.26, 0.61]	2 studies · 360 participants	Moderate
Intervention NR Thromboembolism · patients with prosthetic heart valves Antiplatelet and anticoagulation for patients with prosthetic heart valves (2013) · Cochrane	OR 0.43 [0.32, 0.59]	13 studies · 4122 participants	High
Intervention NR Mortality · patients with prosthetic heart valves Antiplatelet and anticoagulation for patients with prosthetic heart valves (2013) · Cochrane	OR 0.57 [0.42, 0.78]	13 studies · 4122 participants	Moderate
Intervention NR Major Bleeding · patients with prosthetic heart valves Antiplatelet and anticoagulation for patients with prosthetic heart valves (2013) · Cochrane	OR 1.58 [1.14, 2.18]	11 studies · 3856 participants	Moderate
Herbal medicines vs supportive therapy Number of patients died of cardiac failure: Astragaloside injection versus supportive therapy · patients with viral myocarditis Herbal medicines for viral myocarditis (2013) · Cochrane	RR 1.22 [0.34, 4.38]	1 study · 164 participants	Very low
Intervention NR Number of patients with arrhythmia: Garlicin injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis Herbal medicines for viral myocarditis (2013) · Cochrane	RR 0.22 [0.05, 0.86]	1 study · 44 participants	Very low
Intervention NR Number of patients with arrhythmia: Danhong injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis Herbal medicines for viral myocarditis (2013) · Cochrane	RR 0.71 [0.45, 1.04]	1 study · 224 participants	Moderate
Intervention NR Number of patients with premature beat: Astragaloside injection plus supportive therapy versus Acyclovir plus supportive therapy · patients with viral myocarditis Herbal medicines for viral myocarditis (2013) · Cochrane	RR 0.31 [0.09, 0.83]	1 study · 73 participants	Very low
Herbal medicines vs supportive therapy Number of patients with premature beat: Xinshu capsule versus supportive therapy · patients with viral myocarditis Herbal medicines for viral myocarditis (2013) · Cochrane	RR 0.84 [0.56, 0.99]	1 study · 120 participants	Very low
Intervention NR Number of patients with premature beat: Qi Lu decoction plus supportive therapy versus supportive therapy alone · patients with viral myocarditis Herbal medicines for viral myocarditis (2013) · Cochrane	RR 0.71 [0.5, 1]	1 study · 111 participants	Low
Intervention NR Number of patients with premature beat: Shortscape Fleabane injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis Herbal medicines for viral myocarditis (2013) · Cochrane	RR 0.9 [0.67, 1.2]	1 study · 83 participants	Low
Intervention NR Number of patients with premature beat: Astragaloside injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis Herbal medicines for viral myocarditis (2013) · Cochrane	RR 1.09 [0.69, 1.71]	1 study · 93 participants	Low
Intervention NR Number of patients with premature beat: Compound Qiangqi pill plus supportive therapy versus supportive therapy alone · patients with viral myocarditis Herbal medicines for viral myocarditis (2013) · Cochrane	RR 0.8 [0.36, 1.77]	1 study · 14 participants	Moderate
Intervention NR Number of patients with premature beat: Shengmai decoction plus supportive therapy versus supportive therapy alone · patients with viral myocarditis Herbal medicines for viral myocarditis (2013) · Cochrane	RR 1 [0.52, 1.94]	1 study · 14 participants	Moderate
Intervention NR Number of patients with premature beat: Danhong injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis Herbal medicines for viral myocarditis (2013) · Cochrane	RR 0.48 [0.24, 0.96]	1 study · 61 participants	Moderate
Intervention NR Number of patients with arrhythmia: Astragaloside injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis Herbal medicines for viral myocarditis (2013) · Cochrane	RR 0.47 [0.14, 1.18]	1 study · 43 participants	Very low
Music vs standard care Psychological DistressPOMS · people with coronary heart disease Music for stress and anxiety reduction in coronary heart disease patients (2013) · Cochrane	no estimate extracted	5 studies · 228 participants	Low
Music vs standard care Anxiety (all measures)NRS, VAS, HADS, STAI · people with coronary heart disease Music for stress and anxiety reduction in coronary heart disease patients (2013) · Cochrane	no estimate extracted	10 studies · 353 participants	Very low
Music vs standard care State anxiety (MI patients)STAI · people with coronary heart disease Music for stress and anxiety reduction in coronary heart disease patients (2013) · Cochrane	no estimate extracted	6 studies · 243 participants	Low
Music vs standard care Heart ratebpm · people with coronary heart disease Music for stress and anxiety reduction in coronary heart disease patients (2013) · Cochrane	no estimate extracted	13 studies · 828 participants	Very low
Music vs standard care Respiratory ratebreaths per minute · people with coronary heart disease Music for stress and anxiety reduction in coronary heart disease patients (2013) · Cochrane	no estimate extracted	7 studies · 442 participants	Very low
Music vs standard care Systolic blood pressure · people with coronary heart disease Music for stress and anxiety reduction in coronary heart disease patients (2013) · Cochrane	no estimate extracted	11 studies · 775 participants	Low
Music vs standard care PainVAS, NRS · people with coronary heart disease Music for stress and anxiety reduction in coronary heart disease patients (2013) · Cochrane	no estimate extracted	8 studies · 562 participants	Very low
Intervention NR Mortality Mortality at latest · heart transplant recipients Immunosuppressive T‐cell antibody induction for heart transplant recipients (2013) · Cochrane	RR 1.53 [0.85, 2.76]	5 studies · 606 participants	Low
Interleukin‐2 RA vs no induction Cytomegalovirus infection Number of participants diagnosed with CMV infection · heart transplant recipients Immunosuppressive T‐cell antibody induction for heart transplant recipients (2013) · Cochrane	RR 0.86 [0.62, 1.19]	4 studies · 576 participants	Low
Interleukin‐2 RA vs no induction Post‐transplantation lymphoproliferative disorder Number of participants diagnosed with PTLD · heart transplant recipients Immunosuppressive T‐cell antibody induction for heart transplant recipients (2013) · Cochrane	RR 0.61 [0.08, 4.92]	4 studies · 576 participants	Low
Interleukin‐2 RA vs no induction Cancer Number of participants diagnosed with cancer · heart transplant recipients Immunosuppressive T‐cell antibody induction for heart transplant recipients (2013) · Cochrane	RR 1.01 [0.45, 2.28]	4 studies · 576 participants	Low
Interleukin‐2 RA induction vs monoclonal antibody induction Mortality Mortality at latest · heart transplant recipients Immunosuppressive T‐cell antibody induction for heart transplant recipients (2013) · Cochrane	RR 0.8 [0.19, 3.41]	2 studies · 159 participants	Low
Interleukin‐2 RA induction vs monoclonal antibody induction Acute rejection Acute rejection grade 3A or more verified by biopsy · heart transplant recipients Immunosuppressive T‐cell antibody induction for heart transplant recipients (2013) · Cochrane	RR 0.97 [0.77, 1.23]	2 studies · 159 participants	Low
Interleukin‐2 RA induction vs monoclonal antibody induction Infection Number of participants diagnosed with infection · heart transplant recipients Immunosuppressive T‐cell antibody induction for heart transplant recipients (2013) · Cochrane	RR 0.91 [0.54, 1.53]	2 studies · 159 participants	Low
Interleukin‐2 RA induction vs monoclonal antibody induction Cytomegalovirus infection Number of participants diagnosed with CMV infection · heart transplant recipients Immunosuppressive T‐cell antibody induction for heart transplant recipients (2013) · Cochrane	RR 0.94 [0.43, 2.06]	2 studies · 159 participants	Low
Interleukin‐2 RA induction vs monoclonal antibody induction Post‐transplantation lymphoproliferative disorder Number of participants diagnosed with PTLD · heart transplant recipients Immunosuppressive T‐cell antibody induction for heart transplant recipients (2013) · Cochrane	RR 0.31 [0.01, 7.38]	2 studies · 159 participants	Low
Interleukin‐2 RA induction vs monoclonal antibody induction Cancer Number of participants diagnosed with cancer · heart transplant recipients Immunosuppressive T‐cell antibody induction for heart transplant recipients (2013) · Cochrane	RR 0.84 [0.4, 1.77]	2 studies · 159 participants	Low
Interleukin‐2 RA vs polyclonal antibody induction Mortality Mortality at latest · heart transplant recipients Immunosuppressive T‐cell antibody induction for heart transplant recipients (2013) · Cochrane	RR 1.1 [0.65, 1.88]	4 studies · 185 participants	Low
Intervention NR Acute rejection Acute rejection grade 3A or more verified by biopsy · heart transplant recipients Immunosuppressive T‐cell antibody induction for heart transplant recipients (2013) · Cochrane	RR 0.73 [0.46, 1.17]	4 studies · 576 participants	Low
Interleukin‐2 RA vs polyclonal antibody induction Acute rejection Acute rejection grade 3A or more verified by biopsy · heart transplant recipients Immunosuppressive T‐cell antibody induction for heart transplant recipients (2013) · Cochrane	RR 2.43 [1.01, 5.86]	4 studies · 185 participants	Low
Interleukin‐2 RA vs polyclonal antibody induction Infection Number of participants diagnosed with infection · heart transplant recipients Immunosuppressive T‐cell antibody induction for heart transplant recipients (2013) · Cochrane	RR 0.85 [0.71, 1.03]	3 studies · 155 participants	Low