Cochrane · systematic review · CD010652
Colchicine for pericarditis
Alabed, S, Cabello, JB, Irving, GJ, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
11
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 18.2%Moderate 9 · 81.8%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Time to recurrence of pericarditis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Recurrent pericarditis Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Intervention: colchicine with NSAID; Comparison: NSAID alone | HR 0.37 [0.24, 0.58] | 2 studies · 204 participants | Moderate Downgraded: risk of bias |
Acute pericarditis Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Intervention: colchicine with NSAID; Comparison: NSAID alone | HR 0.4 [0.27, 0.61] | 2 studies · 360 participants | Moderate Downgraded: risk of bias |
Adverse effects of colchicine
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total adverse effects Patient reported | RR 1.26 [0.75, 2.12] | 4 studies · 564 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects necessitating stop of therapy Patient reported | RR 1.87 [1.02, 3.41] | 4 studies · 564 participants | Moderate Downgraded: risk of bias |
Recurrences in patients with recurrent pericarditis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) | RR 0.28 [0.17, 0.47] | 2 studies · 204 participants | Moderate Downgraded: risk of bias, imprecision |
months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) | RR 0.36 [0.23, 0.56] | 2 studies · 204 participants | Moderate Downgraded: risk of bias, imprecision |
months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) | RR 0.38 [0.25, 0.58] | 2 studies · 204 participants | Moderate Downgraded: risk of bias, imprecision |
Recurrence rate in patients with acute pericarditis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) | RR 0.36 [0.23, 0.58] | 2 studies · 360 participants | Moderate Downgraded: risk of bias |
months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) | RR 0.4 [0.26, 0.61] | 2 studies · 360 participants | Moderate Downgraded: risk of bias |
months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) | RR 0.41 [0.28, 0.61] | 2 studies · 360 participants | Moderate Downgraded: risk of bias |
Symptom relief for pericarditis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Symptom relief at 72 hours Patient reported | RR 1.4 [1.26, 1.56] | 4 studies · 564 participants | Low Downgraded: risk of bias |