Search review questions

All‐cause mortality · adults with heart failure

All‐cause hospital admissions · adults with heart failure

HF‐related hospital admissions · adults with heart failure

HRQoL (MLWHF only) · adults with heart failure

HRQoL (all measurement scales) · adults with heart failure

All‐cause mortality (during the index hospital admission, or within 30 days, at the longest · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with…

Cardiac complications (as defined by study authors, including cardiac compromise and fatal and non‐fatal myocardial infarction, defined as ECG changes, echocardiological changes, or disproportionate elevation of troponins, during the index hospita... · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with…

Pulmonary complications (as defined by study authors, including pneumonia, embolism, reduced pulmonary function, prolonged ventilation, and pleural effusion, during the index hospital admission) · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with…

Infectious complications (as defined by study authors, including mediastinitis, wound infections, pneumonia, and need for antibiotic therapy, during the index hospital admission) · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with…

Gastrointestinal (GI) bleeding (as defined by study authors, including any upper and lower GI bleeding, during the index hospital admission) · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with…

Renal failure (as defined by study authors, including dialysis, creatinine rise, and oliguria, during the index hospital admission) · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with…

Length of hospital stay (measured in days, during the index hospital admission) · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with…

Medication adherence (self‐reported adherence, questionnaire, tablet counts, medication event monitoring systems, pharmacy prescription data) · people with established arterial occlusive events

Fatal cardiovascular events (percentage of people having fatal cardiovascular events) · people with established arterial occlusive events

Non‐fatal cardiovascular events (percentage of people having non‐fatal cardiovascular events) · people with established arterial occlusive events

Combined CVD events (percentage of people having combined CVD events) · people with established arterial occlusive events

Low‐density lipoprotein cholesterol (mg/dL) (endpoint low‐density lipoprotein cholesterol reading) · people with established arterial occlusive events

Blood pressure (mmHg) (endpoint blood pressure reading) · people with established arterial occlusive events

Heart rate (beats per minute) (endpoint heart rate reading) · people with established arterial occlusive events

Clinical CVD events · people at high risk of or withcardiovascular disease

Clinical CVD events (CVD mortality and non‐fatal MI) · people at high risk of or withcardiovascular disease

Systolic blood pressure (mmHg), change from baseline · people at high risk of or withcardiovascular disease

Diastolic blood pressure (mmHg), change from baseline · people at high risk of or withcardiovascular disease

Anxiety, change from baseline · people at high risk of or withcardiovascular disease

Depression, change from baseline · people at high risk of or withcardiovascular disease

Perceived stress, change from baseline · people at high risk of or withcardiovascular disease

Well‐being · people at high risk of or withcardiovascular disease

Adverse events · people at high risk of or withcardiovascular disease

Smoking cessation · people at high risk of or withcardiovascular disease

Clinical CVD events (CVD mortality, non‐fatal MI and stroke, revascularisations) · people at high risk of or with cardiovascular disease

Systolic blood pressure (mmHg), change from baseline · people at high risk of or withcardiovascular disease

Systolic blood pressure (mmHg), change from baseline · people at high risk of or with cardiovascular disease

Diastolic blood pressure (mmHg), change from baseline · people at high risk of or with cardiovascular disease

Anxiety, change from baseline · people at high risk of or with cardiovascular disease

Depression, change from baseline · people at high risk of or with cardiovascular disease

Perceived stress, change from baseline · people at high risk of or with cardiovascular disease

Well‐being · people at high risk of or with cardiovascular disease

Adverse events · people at high risk of or with cardiovascular disease

Smoking cessation · people at high risk of or with cardiovascular disease

Clinical CVD events · people at high risk of or withcardiovascular disease

Systolic blood pressure (mmHg), change from baseline · people at high risk of or withcardiovascular disease

Diastolic blood pressure (mmHg), change from baseline · people at high risk of or withcardiovascular disease

Diastolic blood pressure (mmHg), change from baseline · people at high risk of or withcardiovascular disease

Anxiety, change from baseline · people at high risk of or withcardiovascular disease

Depression, change from baseline · people at high risk of or withcardiovascular disease

Perceived stress · people at high risk of or withcardiovascular disease

Well‐being · people at high risk of or withcardiovascular disease

Adverse events · people at high risk of or withcardiovascular disease

Smoking cessation · people at high risk of or withcardiovascular disease

Anxiety, change from baseline · people at high risk of or withcardiovascular disease