IBDQ at week 6 · people with active UC
1 finding from 1 review
EQ‐5D at week 6 · people with active UC
1 finding from 1 review
Health‐related quality of life · people with active UC
Infliximab probably leads to higher improved SF‐36 PCS at week 8 compared with placebo (moderate certainty).
1 finding from 1 review
Improved SF‐36 MCS at week 8 · people with active UC
Infliximab probably leads to higher improved SF‐36 MCS at week 8 compared with placebo (moderate certainty).
1 finding from 1 review
Improved IBDQ at week 8 · people with active UC
Adalimumab probably leads to higher improved IBDQ at week 8 compared with placebo (moderate certainty).
1 finding from 1 review
Improved IBDQ at week 52 · people with active UC
Adalimumab probably leads to higher improved IBDQ at week 52 compared with placebo (moderate certainty).
1 finding from 1 review
Failure to induce clinical remission at end of study · patients with induction of remission in ulcerative colitis
Etrolizumab probably leads to lower failure to enter clinical remission at week 10 compared with placebo (moderate certainty).
2 findings from 1 review
Failure to respond at endpoint (6‐12 weeks) · patients with induction of remission in ulcerative colitis
Etrolizumab showed no clear difference in failure to respond at week 10 compared with placebo (moderate certainty).
1 finding from 1 review
Failure to induce endoscopic remission · patients with induction of remission in ulcerative colitis
Etrolizumab showed no clear difference in failure to enter endoscopic remission at week 6 compared with placebo (moderate certainty).
2 findings from 1 review
Adverse events · patients with induction of remission in ulcerative colitis
Etrolizumab probably leads to lower adverse events compared with placebo (moderate certainty).
1 finding from 1 review
Serious adverse events · patients with induction of remission in ulcerative colitis
Etrolizumab showed no clear difference in serious adverse events compared with placebo (low certainty).
1 finding from 1 review
Remission · Participants with Crohn's disease in remission
Budesonide 6 mg showed no clear difference in continued remission at 3 months compared with placebo (low certainty).
3 findings from 1 review
RR 1.25 [1, 1.58]
6 studies · 540 participants
Low
RR 1.15 [0.95, 1.39]
5 studies · 420 participants
Moderate
RR 1.13 [0.94, 1.35]
5 studies · 420 participants
Moderate
Remission · Participants with Crohn's disease in remission
Budesonide 3 mg probably leads to higher continued remission at 3 months compared with placebo (moderate certainty).
3 findings from 1 review
RR 1.29 [1.01, 1.63]
4 studies · 263 participants
Moderate
RR 1.12 [0.83, 1.51]
3 studies · 180 participants
Moderate
RR 1.08 [0.87, 1.34]
5 studies · 442 participants
Moderate
Failure to enter remission or possible remission at 16 weeks (Arora 1999) · adult patients with refractory Crohn's disease
Methotrexate showed no clear difference in failure to enter remission or possible remission at 16 weeks (Arora… compared with placebo (low certainty).
3 findings from 1 review
RR 3 [0.68, 13.31]
1 study · 33 participants
Low
RR 1.05 [0.79, 1.39]
1 study · 52 participants
Low
RR 0.75 [0.61, 0.93]
1 study · 141 participants
Moderate
Withdrawals due to adverse events · adult patients with refractory Crohn's disease
Methotrexate may leads to higher withdrawal due to adverse event (Feagan 1995) compared with placebo (low certainty).
3 findings from 1 review
RR 8 [1.09, 58.51]
1 study · 141 participants
Low
RR 3 [0.13, 70.42]
1 study · 52 participants
Low
RR 8.31 [0.46, 149.21]
1 study · 33 participants
Low
Remission and complete withdrawal from steroids · patients with induction of remission in ulcerative colitis
Methotrexate showed no clear difference in remission and complete withdrawal from steroids compared with placebo (low certainty).
1 finding from 1 review
Mortality Clinical · patients with upper gastrointestinal bleeding
Tranexamic acid probably leads to lower mortality Clinical compared with placebo (moderate certainty).
1 finding from 1 review
Rebleeding · patients with upper gastrointestinal bleeding
Tranexamic acid may leads to lower rebleeding Clinical and endoscopic assessment compared with placebo (low certainty).
1 finding from 1 review
Thromboembolic events · patients with upper gastrointestinal bleeding
Tranexamic acid probably leads to higher any thromboembolic event Clinical and radiological assessment compared with placebo (moderate certainty).
1 finding from 1 review
Surgery Number of participants who underwent surgery · patients with upper gastrointestinal bleeding
Tranexamic acid probably leads to lower surgery Number of participants who underwent surgery compared with placebo (moderate certainty).
1 finding from 1 review