Cochrane · systematic review · CD006618
Methotrexate for induction of remission in ulcerative colitis
Chande, N, Wang, Y, MacDonald, JK, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 66.7%Low 1 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Methotrexate compared to placebo for induction of remission in ulcerative colitis
Population: patients with induction of remission in ulcerative colitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Remission and complete withdrawal from steroids Methotrexate vs placebo | RR 0.96 [0.58, 1.59] | 1 study · 67 participants | Low Downgraded: imprecision |
Methotrexate compared to 6‐mercaptopurine for induction of remission in ulcerative colitis
Population: patients with induction of remission in ulcerative colitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of patients achieved clinical remission Methotrexate vs 6‐mercaptopurine | RR 0.74 [0.43, 1.29] | 1 study · 26 participants | Very low Downgraded: risk of bias, imprecision |
Methotrexate compared to 5‐aminosalicylic acid (5‐ASA) for induction of remission in ulcerative colitis
Population: patients with induction of remission in ulcerative colitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of patients achieved clinical remission Methotrexate vs 5‐aminosalicylic acid (5‐ASA) | RR 2.33 [0.66, 3.64] | 1 study · 20 participants | Very low Downgraded: risk of bias, imprecision |