Cochrane · systematic review · CD006640
Tranexamic acid for upper gastrointestinal bleeding
Bennett, C, Klingenberg, SL, Langholz, E, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 11.1%Low 2 · 22.2%Moderate 6 · 66.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsTranexamic acid vs placebo for upper gastrointestinal bleeding
Population: patients with upper gastrointestinal bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Clinical Tranexamic acid vs placebo | RR 0.6 | 8 studies · 1701 participants | Moderate Downgraded: risk of bias |
Rebleeding Clinical and endoscopic assessment Tranexamic acid vs placebo | RR 0.72 | 7 studies · 1651 participants | Low Downgraded: risk of bias, inconsistency |
Any thromboembolic event Clinical and radiological assessment Tranexamic acid vs placebo | RR 1.86 | 4 studies · 1095 participants | Moderate Downgraded: risk of bias |
Surgery Number of participants who underwent surgery Tranexamic acid vs placebo | RR 0.61 | 7 studies · 1551 participants | Moderate Downgraded: risk of bias |
Transfusion Number needing blood transfusion Tranexamic acid vs placebo | RR 1.02 | 5 studies · 931 participants | Very low Downgraded: risk of bias, indirectness |
Tranexamic acid vs cimetidine or lansoprazole for upper gastrointestinal bleeding
Population: patients with upper gastrointestinal bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Number of participants who died Tranexamic acid vs cimetidine or lansoprazole | RR 0.91 | 2 studies · 720 participants | Moderate Downgraded: risk of bias, indirectness |
Rebleeding Clinical and endoscopic assessment Tranexamic acid vs cimetidine or lansoprazole | RR 0.87 | 2 studies · 720 participants | Moderate Downgraded: risk of bias |
Surgery Number of participants who underwent surgery Tranexamic acid vs cimetidine or lansoprazole | RR 0.83 | 2 studies · 720 participants | Moderate Downgraded: risk of bias |
Transfusion Number of participants who required at least 1 blood transfusion Tranexamic acid vs cimetidine or lansoprazole | RR 0.97 | 2 studies · 720 participants | Low Downgraded: risk of bias, indirectness |