Cochrane · systematic review · CD006640
Tranexamic acid for upper gastrointestinal bleeding
Bennett, C, Klingenberg, SL, Langholz, E, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 11.1%Low 2 · 22.2%Moderate 6 · 66.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyTranexamic acid vs placebo for upper gastrointestinal bleeding
Population: patients with upper gastrointestinal bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Clinical Tranexamic acid vs placebo | RR 0.6 | 8 studies · 1701 participants | Moderate Downgraded: risk of bias |
Rebleeding Clinical and endoscopic assessment Tranexamic acid vs placebo | RR 0.72 | 7 studies · 1651 participants | Low Downgraded: risk of bias, inconsistency |
Any thromboembolic event Clinical and radiological assessment Tranexamic acid vs placebo | RR 1.86 | 4 studies · 1095 participants | Moderate Downgraded: risk of bias |
Surgery Number of participants who underwent surgery Tranexamic acid vs placebo | RR 0.61 | 7 studies · 1551 participants | Moderate Downgraded: risk of bias |
Transfusion Number needing blood transfusion Tranexamic acid vs placebo | RR 1.02 | 5 studies · 931 participants | Very low Downgraded: risk of bias, indirectness |
Tranexamic acid vs cimetidine or lansoprazole for upper gastrointestinal bleeding
Population: patients with upper gastrointestinal bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Number of participants who died Tranexamic acid vs cimetidine or lansoprazole | RR 0.91 | 2 studies · 720 participants | Moderate Downgraded: risk of bias, indirectness |
Rebleeding Clinical and endoscopic assessment Tranexamic acid vs cimetidine or lansoprazole | RR 0.87 | 2 studies · 720 participants | Moderate Downgraded: risk of bias |
Surgery Number of participants who underwent surgery Tranexamic acid vs cimetidine or lansoprazole | RR 0.83 | 2 studies · 720 participants | Moderate Downgraded: risk of bias |
Transfusion Number of participants who required at least 1 blood transfusion Tranexamic acid vs cimetidine or lansoprazole | RR 0.97 | 2 studies · 720 participants | Low Downgraded: risk of bias, indirectness |
Tranexamic acid versus placebo for upper gastrointestinal bleeding
Population: patients with upper gastrointestinal bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Clinical assessment Tranexamic acid vs placebo | RR 0.61 [0.42, 0.89] | 7 studies · 1654 participants | Moderate Downgraded: risk of bias |
Rebleeding or continued bleeding Clinically or endoscopically Tranexamic acid vs placebo | RR 0.73 [0.5, 1.07] | 6 studies · 1604 participants | Low Downgraded: risk of bias |
Surgery Clinically Tranexamic acid vs placebo | RR 0.62 [0.35, 1.09] | 6 studies · 1504 participants | Moderate Downgraded: risk of bias |
Transfusion required Number of patients who required at least one blood transfusion Tranexamic acid vs placebo | RR 1.02 [0.93, 1.11] | 4 studies · 884 participants | Moderate Downgraded: risk of bias |
Any thromboembolic event Number of patients with at least one thromboembolic event Tranexamic acid vs placebo | RR 1.86 [0.66, 5.24] | 3 studies · 1048 participants | Low Downgraded: risk of bias |
Tranexamic acid versus cimetidine or lansoprazole for upper gastrointestinal bleeding
Population: patients with upper gastrointestinal bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Clinically Tranexamic acid vs cimetidine or lansoprazole | RR 0.91 [0.5, 1.64] | 2 studies · 720 participants | Moderate Downgraded: risk of bias |
Bleeding Clinically or endoscopically Tranexamic acid vs cimetidine or lansoprazole | RR 0.87 [0.64, 1.2] | 2 studies · 720 participants | Moderate Downgraded: risk of bias |
Surgery Clinically Tranexamic acid vs cimetidine or lansoprazole | RR 0.83 [0.54, 1.26] | 2 studies · 720 participants | Moderate Downgraded: risk of bias |
Transfusion requirements Number of patients who required at least one blood transfusion Tranexamic acid vs cimetidine or lansoprazole | RR 0.97 [0.78, 1.22] | 2 studies · 720 participants | Moderate Downgraded: risk of bias |