Methotrexate vs placebo: Withdrawals due to adverse events
Methotrexate may leads to higher withdrawal due to adverse event (Feagan 1995) compared with placebo (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Methotrexate vs placebo Withdrawal due to adverse event (Feagan 1995) · Adult patients with refractory Crohn's disease Methotrexate may leads to higher withdrawal due to adverse event (Feagan 1995) compared with placebo (low certainty). Methotrexate for induction of remission in refractory Crohn's disease (2014) · Cochrane Headline outcomes only | RR 8 [1.09, 58.51] | 1 study · 141 participants | Low |
Methotrexate vs placebo Withdrawal due to adverse event (Oren 1997) · Adult patients with refractory Crohn's disease Methotrexate showed no clear difference in withdrawal due to adverse event (Oren 1997) compared with placebo (low certainty). Methotrexate for induction of remission in refractory Crohn's disease (2014) · Cochrane Headline outcomes only | RR 3 [0.13, 70.42] | 1 study · 52 participants | Low |
Methotrexate vs placebo Withdrawal due to adverse event (Arora 1999) · Adult patients with refractory Crohn's disease Methotrexate showed no clear difference in withdrawal due to adverse event (Arora 1999) compared with placebo (low certainty). Methotrexate for induction of remission in refractory Crohn's disease (2014) · Cochrane Headline outcomes only | RR 8.31 [0.46, 149.21] | 1 study · 33 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Methotrexate for induction of remission in refractory Crohn's disease 2014 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.