What do systematic reviews say?

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

Occlusal adjustment as an adjunct to non-surgical periodontal therapy showed no clear difference in probing (pocket) depth change (difference in mean reduction, mm) compared with non-surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  2 years
  MD 0.04 [-0.19, 0.27]
  1 study · 50 participants
  GRADE not reported

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

The review found no eligible studies for this question.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  Minimum 3 months (planned)
  no estimate extracted
  0 studies
  No studies found

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

The review found no eligible studies for this question.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  Minimum 3 months (planned)
  no estimate extracted
  0 studies
  No studies found

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

The review found no eligible studies for this question.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  Minimum 3 months (planned)
  no estimate extracted
  0 studies
  No studies found

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

Occlusal adjustment as an adjunct to surgical periodontal therapy led to higher clinical attachment level change (mean gain, mm) compared with surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  2 years
  MD 0.40 [0.05, 0.75]
  1 study · 50 participants
  GRADE not reported

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

The review found no eligible studies for this question.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  Minimum 3 months (planned)
  no estimate extracted
  0 studies
  No studies found

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

Occlusal adjustment as an adjunct to surgical periodontal therapy showed no clear difference in probing (pocket) depth change (difference in mean reduction, mm) compared with surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  2 years
  MD 0.01 [-0.20, 0.22]
  1 study · 50 participants
  GRADE not reported

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

Occlusal adjustment as an adjunct to non-surgical periodontal therapy led to higher clinical attachment level change (mean gain, mm) compared with non-surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  2 years
  MD 0.38 [0.04, 0.72]
  1 study · 50 participants
  GRADE not reported

Primary closure of the extraction socket with a mucoperiosteal flap vs Application of platelet-rich fibrin (PRF) without primary closure

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  90 days
  All participants had complete mucosal coverage without any signs of MRONJ at the final control examination 90 days postoperatively (77 randomised; 1 RCT); no case of postoperative MRONJ in either group; effect not…
  1 study · 77 participants
  GRADE not reported

Teriparatide 20 microg daily in addition to standard care vs placebo + standard care

Teriparatide 20 microg daily in addition to standard care showed no clear difference in healing of MRONJ (resolution of lesions) compared with placebo in addition to standard care (low certainty).

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  52 weeks
  RR 0.96 [0.31, 2.95]
  1 study · 33 participants
  Low

Concentrated growth factor (CGF) and primary wound closure vs primary closure

It is very uncertain whether concentrated growth factor (CGF) and primary wound closure changes healing of MRONJ (soft tissue healing) compared with primary wound closure only (very low certainty).

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  6 months
  RR 1.38 [0.81, 2.34]
  1 study · 28 participants
  Very low

Delicate surgery and wound closure by primary intention vs Non-traumatic tooth avulsion and wound closure by secondary intention

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes
  In both study arms, no case of postoperative MRONJ was observed (700 participants; 1 RCT); effect not estimable.
  1 study · 700 participants
  GRADE not reported

Hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy vs conventional therapy

It is very uncertain whether hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy changes healing of MRONJ compared with conventional therapy (very low certainty).

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  up to 24 months (at last follow-up)
  RR 1.56 [0.77, 3.18]
  1 study · 46 participants
  Very low

Dental examinations at three-month intervals and preventive treatments vs usual care

It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence proportion) compared with standard care (very low certainty).

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  mean 32 months
  RR 0.10 [0.02, 0.39]
  1 study · 253 participants
  Very low

Teriparatide 56.5 microg weekly in addition to standard care vs Teriparatide 20 microg daily in addition to standard care

It is very uncertain whether teriparatide 56.5 microg weekly in addition to standard care changes healing of MRONJ (remission) compared with teriparatide 20 microg daily in addition to standard care (very low certainty).

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  6 months
  RR 0.60 [0.25, 1.44]
  1 study · 12 participants
  Very low

Subperiosteal prepared (SPP) wound closure after tooth extraction vs Epiperiosteal prepared (EPP) wound closure after tooth extraction

Subperiosteal prepared (SPP) wound closure after tooth extraction showed no clear difference in MRONJ after tooth extraction (incidence proportion) compared with epiperiosteal prepared (EPP) wound closure after tooth extraction (low certainty).

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  6 months
  RR 0.09 [0.00, 1.56]
  1 study · 132 participants
  Low

Hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy vs conventional therapy

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  6 months
  QoL measured with the Duke Health Profile; only within-group comparisons were provided; no score values, so a between-group analysis was not possible.
  1 study
  GRADE not reported

Dental extraction protocol with plasma rich in growth factors (PRGF) inserted into the postextraction alveolus vs Standard dental extraction protocol without PRGF

It is very uncertain whether dental extraction protocol with plasma rich in growth factors (PRGF)… changes MRONJ (incidence proportion) compared with standard dental extraction protocol without PRGF (very low certainty).

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  24 to 60 months
  RR 0.08 [0.00, 1.51]
  1 study · 176 participants
  Very low

Dental examinations at three-month intervals and preventive treatments vs usual care

It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence rate: cases per patient-year) compared with standard care (very low certainty).

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  mean 28.8 months
  rate ratio 0.18 [0.04, 0.74]
  1 study · 253 participants
  Very low

Zygomatic implants for retaining a maxillary obturator vs Non-implant retained obturators, local and regional flaps, or microvascular free flaps

The review found no eligible studies for this question.

• Interventions for replacing missing teeth: dental implants in zygomatic bone for the rehabilitation of the severely… 2013 · Cochrane All outcomes

  At least 1 year in function
  Results (Effects of interventions): we could not identify any eligible randomised controlled trials (RCTs).
  0 studies
  No studies found