Question · asked by 1 review
Concentrated growth factor (CGF) and primary wound closure vs primary closure: Healing of MRONJ (soft tissue healing)
- Population
- Women with osteoporosis and established MRONJ
- Intervention
- Concentrated growth factor (CGF) and primary wound closure
- Comparison
- primary closure
- Outcome
- Healing of MRONJ (soft tissue healing)
It is very uncertain whether concentrated growth factor (CGF) and primary wound closure changes healing of MRONJ (soft tissue healing) compared with primary wound closure only (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Concentrated growth factor (CGF) and primary wound closure vs Primary wound closure only Healing of MRONJ (soft tissue healing) · Women with osteoporosis and established MRONJ · 6 months It is very uncertain whether concentrated growth factor (CGF) and primary wound closure changes healing of MRONJ (soft tissue healing) compared with primary wound closure only (very low certainty). Interventions for managing medication‐related osteonecrosis of the jaw (2022) · Cochrane All outcomes | RR 1.38 [0.81, 2.34] | 1 study · 28 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes | 2021-06 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.