Findings

What do systematic reviews say?

2,355 questions · 2,459 findings · 279 reviews

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No studies found 556 · 22.6%GRADE not reported 490 · 19.9%Very low 593 · 24.1%Low 479 · 19.5%Moderate 243 · 9.9%High 98 · 4%

Intervention not reported

Pain score for highest level before leaving clinic (100 mm VAS) · women with IUC being inserted

The intervention probably leads to higher pain score for highest level before leaving clinic (100 mm VAS) (moderate certainty).

1 finding from 1 review

Interventions for pain with intrauterine device insertion 2015 · Cochrane Headline outcomes only
MD 7.6 [6.48, 8.72]
105 participants
Moderate

Summary of findings table 3: comparison of operation types: firebreak skin grafting vs z‐plasty closure of fasciectomy

Hypoaesthesia Major outcome group 5 (adverse effects) · 79 participants (Ullah 2009)

1 finding from 1 review

Surgery for Dupuytren's contracture of the fingers 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 79 participants
Low

Summary of findings table 1: comparison of operation types: early results of needle fasciotomy vs limited fasciectomy

Paraesthesia · 125 hands in 121 participants with Dupuytren's disease of the fingers for early outcomes (van Rijssen 2006)

1 finding from 1 review

Surgery for Dupuytren's contracture of the fingers 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 117 participants
Low

Lidocaine vs lidocaine with adrenaline

Duration of anaesthesiaTime perioda · patients with digital nerve blocks

1 finding from 1 review

Adrenaline with lidocaine for digital nerve blocks 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Low

GnRH‐a + raloxifene vs GnRH‐a ± placebo

Severity of vasomotor symptoms · patients with uterine fibroids

1 finding from 1 review

Add‐back therapy with GnRH analogues for uterine fibroids 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 91 participants
Low

Low‐level laser therapy vs Placebo (sham) laser therapy

Patient-reported altered sensation (spontaneous or evoked: anaesthesia/paraesthesia/dysaesthesia/hyperalgesia/allodynia) · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve

It is very uncertain whether low-level laser therapy (photon-plus GaAlAs diode laser; 70 mW… changes patient-reported altered sensation (spontaneous or evoked:… compared with placebo (sham) laser therapy (very low certainty).

2 findings from 1 review

Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
Lip
MD 21.79 [5.29, 38.29]
1 study · 13 participants
Very low
Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
Chin
MD 8.40 [3.67, 13.13]
1 study · 13 participants
Very low

Resorbable barrier (membrane) to seal the lateral window vs No membrane to seal the lateral window

Prosthesis failure · Patients undergoing lateral-window maxillary sinus lift

Resorbable barrier (membrane) to seal the lateral window showed no clear difference in prosthesis failure compared with no membrane to seal the lateral window; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes
1 year after loading
OR 2.63 [0.75, 9.14]
1 study · 104 participants
GRADE not reported

Osteotomes with mallet (Summers' technique) vs Rotary instruments (Cosci technique)

Prosthesis failure · Patients undergoing crestal maxillary sinus lift

1 finding from 1 review

Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes
3 years after loading
Checchi 2010 (split-mouth, N = 12): no prosthetic failures in either group.
1 study · 12 participants
GRADE not reported

Rotary instruments to open the lateral sinus window vs Piezosurgery to open the lateral sinus window

Prosthesis failure · Patients undergoing lateral-window maxillary sinus lift

1 finding from 1 review

Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes
1 year after loading
Rickert 2013 (split-mouth, N = 36): no prosthesis failures in either group.
1 study · 36 participants
GRADE not reported

One-stage crestal-approach sinus lift with autogenous bone and 8 mm implants vs Lateral-window sinus lift with 50% autogenous bone/50% Bio-Oss and implants at least 10 mm long

Prosthesis failure · Patients with 3 to 6 mm of residual bone height at the sinus floor

One-stage crestal-approach sinus lift with autogenous bone and 8 mm… showed no clear difference in prosthesis failure compared with lateral-window sinus lift with 50% autogenous bone/50% Bio-Oss and…; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes
5 years after loading
OR 0.47 [0.04, 5.69]
1 study · 40 participants
GRADE not reported

Sinus lift with bone graft (granular Bio-Oss) vs Sinus lift without bone graft (Inion resorbable rigid barrier maintaining space / no bone)

Prosthesis failure · Patients with an atrophic maxillary sinus requiring augmentation (1 to 5 mm residual bone height)

Sinus lift with bone graft (granular Bio-Oss) showed no clear difference in prosthesis failure compared with sinus lift without bone graft (Inion resorbable rigid barrier…; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes
1 year after loading
OR 0.63 [0.10, 4.22]
1 study · 44 participants
GRADE not reported

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam

Continuation of status requiring a different drug or general anaesthesia · patients with status epilepticus

Lorazepam IV probably leads to lower continuation of status requiring a different drug or general… compared with diazepam IV (moderate certainty).

1 finding from 1 review

Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
RR 0.63 [0.45, 0.88]
3 studies · 264 participants
Moderate

Primary comparison for continuous passive motion (CPM) vs no CPM

Manipulation under anaesthesia · hospitalised patients who have undergone knee replacement surgery

It is very uncertain whether primary comparison for continuous passive motion (CPM) changes manipulation under anaesthesia Counts of manipulation under… compared with no CPM (very low certainty).

1 finding from 1 review

Continuous passive motion following total knee arthroplasty in people with arthritis 2014 · Cochrane Headline outcomes only
RR 0.34 [0.13, 0.89]
8 studies · 581 participants
Very low

Exercise vs control

Change in hot flushes/night sweats Self‐report · women with vasomotor menopausal symptoms

1 finding from 1 review

Exercise for vasomotor menopausal symptoms 2014 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 454 participants
Low

Exercise vs yoga

Change in hot flushes/night sweats Self‐report · women with vasomotor menopausal symptoms

1 finding from 1 review

Exercise for vasomotor menopausal symptoms 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 279 participants
Low

Computer‐assisted reconstruction surgery vs conventional operating techniques

Activity level: Tegner score ( 0 to 10; higher scores = greater activity) · People, primarily adults, undergoing ACL reconstruction surgery

1 finding from 1 review

Computer‐assisted surgery for knee ligament reconstruction 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

SULPIRIDE vs placebo

Mental state: 2. Specific‐ Positive symptoms, total score‐ average endpoint scores (SADS‐C‐PD scale, lower = better) · patients with schizophrenia

1 finding from 1 review

Sulpiride versus placebo for schizophrenia 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

SULPIRIDE vs placebo

Mental state: average score for negative symptoms ‐ by short term Manchester Scale, negative subset endpoint. Scale from: 0 to 20. · patients with schizophrenia

1 finding from 1 review

Sulpiride versus placebo for schizophrenia 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Intervention not reported

Change in number of hot flushes/24 h ( · perimenopausal and postmenopausal women with vasomotor symptoms

1 finding from 1 review

Relaxation for perimenopausal and postmenopausal symptoms 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Very low

Intervention not reported

Improvement in severity of hot flushes ( · perimenopausal and postmenopausal women with vasomotor symptoms

1 finding from 1 review

Relaxation for perimenopausal and postmenopausal symptoms 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Very low