Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

155 questions · 173 findings · 22 reviews · Heart

No studies found 32 · 18.5%GRADE not reported 1 · 0.6%Very low 38 · 22%Low 66 · 38.2%Moderate 30 · 17.3%High 6 · 3.5%

Psychological interventions vs usual care

Change in depression score ( · adolescents and adults with congenital heart disease
2 findings from 1 review

Ultrafiltration (UF) vs usual care

Heart failure‐related rehospitalisation · people with AHF

Ultrafiltration (UF) showed no clear difference in heart failure‐related rehospitalisation compared with usual care (UC) (low certainty).

1 finding from 1 review

Ultrafiltration (UF) vs usual care

New initiation of renal replacement therapy – at longest available · people with AHF

Ultrafiltration (UF) showed no clear difference in new initiation of renal replacement therapy – at longest available compared with usual care (UC) (low certainty).

1 finding from 1 review

Ultrafiltration (UF) vs usual care

Complications of central line insertion – in hospital · people with AHF

It is very uncertain whether ultrafiltration (UF) changes complications of central line insertion – in hospital compared with usual care (UC) (very low certainty).

1 finding from 1 review

Angiotensin receptor neprilysin inhibitors (ARNIs) vs usual care

Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor neprilysin inhibitors (ARNIs) showed no clear difference in cardiovascular mortality (RR) Median compared with usual care (moderate certainty).

1 finding from 1 review

Angiotensin receptor neprilysin inhibitors (ARNIs) vs usual care

Time to first hospitalisation for heart failure during · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor neprilysin inhibitors (ARNIs) showed no clear difference in heart failure hospitalisation, first (RR) Range of compared with usual care (moderate certainty).

1 finding from 1 review

Angiotensin receptor neprilysin inhibitors (ARNIs) vs usual care

Hyperkalaemia · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor neprilysin inhibitors (ARNIs) showed no clear difference in hyperkalaemia Range of compared with usual care (moderate certainty).

1 finding from 1 review

Angiotensin receptor neprilysin inhibitors (ARNIs) vs usual care

All‐cause mortality (RR) Range of · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor neprilysin inhibitors (ARNIs) leads to lower all‐cause mortality (RR) Range of compared with usual care (high certainty).

1 finding from 1 review