Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

95 questions · 96 findings · 13 reviews

No studies found 33 · 34.4%GRADE not reported 0 · 0%Very low 14 · 14.6%Low 36 · 37.5%Moderate 13 · 13.5%High 0 · 0%

Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin

Death from all causes during treatment (range 6 days to 16 days) · acute ischaemic stroke

Low‐molecular‐weight heparins or heparinoids showed no clear difference in death from all causes during treatment (range 6 days to 16 days) compared with unfractionated heparin (low certainty).

1 finding from 1 review

Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin

Death from all causes during · acute ischaemic stroke

Low‐molecular‐weight heparins or heparinoids showed no clear difference in death from all causes during compared with unfractionated heparin (low certainty).

1 finding from 1 review

Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin

Deep vein thrombosis · acute ischaemic stroke

Low‐molecular‐weight heparins or heparinoids may leads to lower deep vein thrombosis during treatment period (range 6 days to 16 days) compared with unfractionated heparin (low certainty).

1 finding from 1 review

Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin

Pulmonary embolism · acute ischaemic stroke

Low‐molecular‐weight heparins or heparinoids showed no clear difference in pulmonary embolism during treatment period (range 6 days to 16 days) compared with unfractionated heparin (low certainty).

1 finding from 1 review

Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin

Symptomatic intracranial haemorrhage/haemorrhagic transformation of the cerebral infarct during treatment period (range 6 days to 16 days)⁹ · acute ischaemic stroke

Low‐molecular‐weight heparins or heparinoids showed no clear difference in symptomatic intracranial haemorrhage/haemorrhagic transformation of… compared with unfractionated heparin (low certainty).

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Success rate of replantation1 (analysed by participant) · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin changes success rate of replantation1 (analysed by participant, compared with unfractionated heparin (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Success rate of replantation1 (analysed by digit, · patients undergoing digital replantation after traumatic amputation

Low molecular weight heparin showed no clear difference in success rate of replantation1 (analysed by digit, compared with unfractionated heparin (low certainty).

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Incidence of compromised microcirculation requiring invasive intervention (re‐exploration) (analysed by digit, · patients undergoing digital replantation after traumatic amputation

The review found no eligible studies for this question.

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Incidence of compromised microcirculation requiring invasive intervention (incision) (analysed by participant/digit, · patients undergoing digital replantation after traumatic amputation

The review found no eligible studies for this question.

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Microvascular insufficiency due to vessel occlusion ‐ arterial occlusion (analysed by digit, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin changes microvascular insufficiency due to vessel occlusion ‐ arterial… compared with unfractionated heparin (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Microvascular insufficiency due to vessel occlusion ‐ venous occlusion (analysed by participant, · patients undergoing digital replantation after traumatic amputation

It is very uncertain whether low molecular weight heparin changes microvascular insufficiency due to vessel occlusion ‐ venous… compared with unfractionated heparin (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs unfractionated heparin

Complication and adverse reactions ‐ wound bleeding (analysed by participant, · patients undergoing digital replantation after traumatic amputation

Low molecular weight heparin showed no clear difference in complication and adverse reactions ‐ wound bleeding (analysed by… compared with unfractionated heparin (low certainty).

1 finding from 1 review