dmfs index score (decayed, missing, filled primary surfaces; range 0-80) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
Advice about a healthy diet (including breastfeeding promotion and… showed no clear difference in dmfs index score (decayed, missing, filled primary surfaces; range… compared with standard care (low certainty).
1 finding from 1 review
Caries presence in primary teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
Advice about a healthy diet (including breastfeeding promotion and… probably leads to lower caries presence in primary teeth compared with standard care (moderate certainty).
1 finding from 1 review
Caries severity (d1 + mfs >= 5) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
Advice about a healthy diet (including breastfeeding promotion and… led to lower caries severity (d1 + mfs >= 5) compared with standard care; GRADE not reported.
1 finding from 1 review
Mother self-reported oral health behaviours and attitudes · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
1 finding from 1 review
Caries in primary teeth: dmft (3 years) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
It is very uncertain whether advice about a healthy diet (including breastfeeding promotion and… changes dmft index score (decayed, missing, filled primary teeth; range 0-20) compared with standard care (very low certainty).
1 finding from 1 review
Child oral health behaviours · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
1 finding from 1 review
Adverse events for mother or child · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
1 finding from 1 review
Enamel/dental hard-tissue changes and e-liquid cariogenic properties (demineralization, colour change, pH, sugar content, metals) · Oral bacteria (streptococci), dental hard tissue (enamel/dentin) and e-liquids studied in vitro/ex vivo (with a few clinical microbiome…
In vitro evidence suggests e-liquids are often acidic and sugar-containing and can alter enamel/dentin colour and properties, supporting a plausible cariogenic effect, but findings are heterogeneous and not pooled (ungraded, narrative).
1 finding from 1 review
Intervention not reported
Sugar‐sweetened beverage consumption · children aged six months to six years
The intervention showed no clear difference in sugar‐sweetened beverage consumption (moderate certainty).
1 finding from 1 review
Participants with hyperglycemia "Transient hyperglycemia" or blood sugar increase ≥ 50 mg/dL · people with radicular low back pain (not due to spinal stenosis)
Systemic corticosteroids showed no clear difference in participants with hyperglycemia "Transient hyperglycemia" or blood… compared with placebo (low certainty).
1 finding from 1 review
Intervention not reported
NNS versus sugar
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
NNS versus sugar NNS: aspartame, saccharin, sodium‐cyclamate
1 finding from 1 review
Sugar + egg white · people with pressure ulcers
It is very uncertain whether NMA evidence for individual network: proportion with complete… changes sugar + egg white compared with saline gauze (very low certainty).
1 finding from 1 review
RR 0.7 [0.03, 15.62]
Studies not reported
Very low
Intervention not reported
Number of infants with hypoglycaemia Blood sugar level: glucose meter or laboratory‐based plasma glucose level · newborn infants who require a central venous catheter
The intervention leads to lower number of infants with hypoglycaemia Blood sugar level: glucose… (high certainty).
1 finding from 1 review
Change in Mutans streptococci (MS) and Lactobacilli in saliva · Schoolchildren (6-9 years), high caries risk
The single stevia trial (Cocco 2019) reported a significant reduction in salivary Mutans streptococci and lactobacilli, but gave no effect size and was not GRADE-rated.
1 finding from 1 review
Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis. 2024 All outcomes42 days · Schoolchildren in Italy, high caries risk; sweetener delivered as a daily snack · Single study (Cocco 2019); not pooled
Cocco 2019 (the only high-intensity sweetener trial): the stevia snack showed a significant decrease in MS (P < .01) and in lactobacilli (P = .03) versus baseline, whereas the white-sugar snack showed no significant…
1 study · 271 participants
GRADE not reported
Effects of non-stevia high-intensity sweeteners (aspartame, sucralose, saccharin) on cariogenic bacteria in dental plaque or saliva · healthy people
No eligible studies evaluated high-intensity sweeteners such as aspartame, sucralose, or saccharin for their effect on cariogenic bacteria.
1 finding from 1 review
Cardiovascular events · Adults without diabetes or CVD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All‐cause mortality · Adults without diabetes or CVD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Systolic blood pressure · Adults without diabetes or CVD
1 finding from 1 review
Cholesterol mg/dL · Adults without diabetes or CVD
1 finding from 1 review