Number with treatment stopped due to adverse effects · Adults or adolescents with opioid dependence
Buprenorphine showed no clear difference in number with treatment stopped due to adverse effects compared with alpha2‐adrenergic agonists (low certainty).
1 finding from 1 review
Number completing withdrawal treatment · Adults or adolescents with opioid dependence
Buprenorphine probably leads to higher number completing withdrawal treatment compared with alpha2‐adrenergic agonists (moderate certainty).
1 finding from 1 review
Dropout ‐ Dropouts: excluding studies with high risk of bias objective · patients with cocaine abuse and dependence
Antidepressants showed no clear difference in dropout ‐ Dropouts: excluding studies with high risk of bias objective compared with placebo according to any definition (moderate certainty).
1 finding from 1 review
Abstinence · patients with cocaine abuse and dependence
Antidepressants showed no clear difference in abstinence, for at least three consecutive weeks objective compared with placebo according to any definition (high certainty).
1 finding from 1 review
Number withdrawn due to adverse events · patients with cocaine abuse and dependence
Antidepressants showed no clear difference in adverse events ‐ Withdrawn due to adverse events compared with placebo according to any definition (moderate certainty).
1 finding from 1 review
Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use
It is very uncertain whether pregabalin changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).
1 finding from 1 review
Benzodiazepine discontinuation, longest · adults who withdraw from chronic benzodiazepine use
1 finding from 1 review
Benzodiazepine withdrawal symptoms, end of intervention · adults who withdraw from chronic benzodiazepine use
1 finding from 1 review
Benzodiazepine withdrawal symptoms, longest · adults who withdraw from chronic benzodiazepine use
1 finding from 1 review
Dropout · opiate‐dependent pregnant women
Methadone showed no clear difference in dropout rate compared with buprenorphine (moderate certainty).
1 finding from 1 review
Use of Primary Substance · opiate‐dependent pregnant women
Methadone showed no clear difference in use of primary substance compared with buprenorphine (low certainty).
1 finding from 1 review
Birthweight (g) · opiate‐dependent pregnant women
1 finding from 1 review
APGAR scoreScale from: 0 to 10 · opiate‐dependent pregnant women
1 finding from 1 review
Number treated for NAS · opiate‐dependent pregnant women
Methadone showed no clear difference in number treated for NAS compared with buprenorphine (low certainty).
1 finding from 1 review
Proportion of mothers with serious adverse events ( · opiate‐dependent pregnant women
Methadone showed no clear difference in serious adverse events for the mother compared with buprenorphine (low certainty).
1 finding from 1 review
Serious adverse events for the child · opiate‐dependent pregnant women
Methadone showed no clear difference in serious adverse events for the child compared with buprenorphine (low certainty).
1 finding from 1 review
Alcohol use prevalence Up to 4 years post intervention impact of family/parent interventions compared to control on the prevalence of alcohol consumption or drunkenness · parents/children
1 finding from 1 review
Alcohol use prevalence Up to 4 years post intervention impact of family/parent interventions compared to control on the prevalence of alcohol consumption or drunkenness · parents/children
1 finding from 1 review
Intervention not reported
Preterm birth (< 37 weeks gestation) (Any psychosocial intervention vs. control)
The intervention showed no clear difference in preterm birth (< 37 weeks gestation) (Any psychosocial intervention… (moderate certainty).
1 finding from 1 review
Drop‐out (end of treatment) · patients with opiate dependent adolescents
Buprenorphine showed no clear difference in drop out Number of participants who did not complete the… compared with clonidine (moderate certainty).
1 finding from 1 review