Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

458 questions · 466 findings · 48 reviews · Schizophrenia

No studies found 87 · 18.7%GRADE not reported 82 · 17.6%Very low 153 · 32.8%Low 111 · 23.8%Moderate 19 · 4.1%High 14 · 3%

ZUCLOPENTHIXOL DECANOATE vs placebo

Quality of life/satisfaction with care for either recipients of care or carers: significant change in quality of life/satisfaction · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

ASENAPINE vs placebo

Global state: No clinically important change (as defined by the original studies) · adults with schizophrenia

ASENAPINE may leads to lower global state: No clinically important change CGI‐I compared with PLACEBO (low certainty).

1 finding from 1 review

ASENAPINE vs placebo

Clinical response: no clinically significant response in mental state · adults with schizophrenia

It is very uncertain whether ASENAPINE changes mental state: No clinically important change PANSS compared with PLACEBO (very low certainty).

1 finding from 1 review

ASENAPINE vs placebo

Adverse effects: Incidence of serious adverse effects · adults with schizophrenia

It is very uncertain whether ASENAPINE changes adverse effects: Incidence of serious adverse effects compared with PLACEBO (very low certainty).

1 finding from 1 review

ASENAPINE vs placebo

Adverse effects: 1. Clinically significant extrapyramidal side effects (2‐10 weeks) vs. standard higher dose (> 7.5‐15 mg/day) · adults with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

ASENAPINE vs placebo

Leaving the study early · adults with schizophrenia

It is very uncertain whether ASENAPINE changes leaving the study early ‐ any reason compared with PLACEBO (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs placebo

Global state: no overall improvement (psychiatrist ‐ rated) · patients with schizophrenia

It is very uncertain whether CHLORPROMAZINE changes global state: no overall improvement (psychiatrist ‐ rated) compared with PLACEBO (very low certainty).

1 finding from 1 review