Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,227 questions · 2,562 findings · 156 reviews · All outcomes

No studies found 297 · 11.6%GRADE not reported 1,616 · 63.1%Very low 405 · 15.8%Low 144 · 5.6%Moderate 81 · 3.2%High 19 · 0.7%

Leukemia (oral health status) vs None (descriptive; compared by treatment location)

Oral health problems (mucositis, caries, candidiasis) · Children with leukemia in the United Arab Emirates

One study found oral problems in 60% of children with leukemia, most common during maintenance therapy and among those treated locally (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Down syndrome (oral health status) vs Healthy controls

Oral health status (caries, DMFT, calculus, erosion, malocclusion, treatment indices) · Children with Down syndrome in Dubai

One study found children with Down syndrome had similar caries prevalence but higher DMFT, calculus, erosion and malocclusion than controls, with better restorative-care access (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Cerebral palsy (oral health status) vs Healthy controls

Oral health status (caries, gingivitis, calculus, treatment indices) · Children with cerebral palsy in Dubai

One study found children with cerebral palsy had caries and gingivitis similar to matched controls but more calculus and anomalies, with lower restorative care despite greater need (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Oral hygiene care training of carers vs No training (or a placebo training session) of carers

Oral health knowledge of carers (medium term) · People with mixed levels of ID (age range unclear); setting residential

Oral hygiene care training of carers may leads to higher oral health knowledge of carers (medium term) compared with no training (or a placebo training session) of carers (low certainty).

1 finding from 1 review

Epidermal growth factor (EGF), oral spray vs placebo

Oral mucositis (severe) · Adults with cancer receiving treatment

Epidermal growth factor (EGF), oral spray showed no clear difference in oral mucositis (severe) compared with placebo; GRADE not reported.

1 finding from 1 review

Epidermal growth factor (EGF), oral spray vs placebo

Oral mucositis (moderate to severe) · Adults with cancer receiving treatment

Epidermal growth factor (EGF), oral spray showed no clear difference in oral mucositis (moderate to severe) compared with placebo; GRADE not reported.

2 findings from 1 review

Beta-thalassemia major vs Healthy Emirati children

Oral health status (caries, calculus, gingivitis) · Children with beta-thalassemia major in Dubai

One study found higher caries and calculus but lower gingivitis and restorative care in children with beta-thalassemia major compared with healthy Emirati children (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Intestinal trefoil factor (ITF), oral spray vs placebo

Oral mucositis (moderate to severe) · Adults receiving chemotherapy alone for colorectal cancer

Intestinal trefoil factor (ITF), oral spray led to lower oral mucositis (moderate to severe) compared with placebo; GRADE not reported.

1 finding from 1 review

Intestinal trefoil factor (ITF), oral spray vs placebo

Oral mucositis (any severity) · Adults receiving chemotherapy alone for colorectal cancer

Intestinal trefoil factor (ITF), oral spray led to lower oral mucositis (any severity) compared with placebo; GRADE not reported.

1 finding from 1 review

Intestinal trefoil factor (ITF), oral spray vs placebo

Oral mucositis (severe) · Adults receiving chemotherapy alone for colorectal cancer

Intestinal trefoil factor (ITF), oral spray showed no clear difference in oral mucositis (severe) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral prednisone plus curcuminoids (adjunctive) vs Oral prednisone plus placebo

Reduction in pain · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review

Oral hygiene knowledge and practices assessment vs None (descriptive prevalence review; subgroup analyses by urban/rural status, country and year)

Oral hygiene knowledge and practices · Children and adolescents in the United Arab Emirates

Oral hygiene knowledge and practices among UAE children and adolescents were generally suboptimal and variable across studies, with better practices among females (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: oral breathing (questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: oral breathing (questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Visual examination (VE) vs Reference standard: examination and clinical evaluation by a physician/clinician with specialist knowledge or training (long-term follow-up accepted for those screened negative)

Specificity for detection of oral cavity cancer/OPMD · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
1 finding from 1 review

Visual examination (VE) vs Reference standard: examination and clinical evaluation by a physician/clinician with specialist knowledge or training (long-term follow-up accepted for those screened negative)

Sensitivity for detection of oral cavity cancer/OPMD · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
1 finding from 1 review

Oral health knowledge, attitudes and practices assessment vs None (descriptive prevalence review; subgroup analyses by urban/rural status, country and year)

Mother self-reported oral health behaviours and attitudes · Mothers and caregivers of children in the United Arab Emirates

Mothers and caregivers often had adequate knowledge/attitudes but improper oral-health practices and low dental-service use, associated with education and occupation (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Oral care vs No oral care

Outcome not reported · Residents of nursing homes and other long-term care facilities

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine (mouthrinse or gel), as part of oral hygiene care vs placebo or usual care

Caregivers' preferences for oral hygiene care · Critically ill patients (adults and children) receiving mechanical ventilation in ICU

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine (mouthrinse or gel), as part of oral hygiene care vs placebo or usual care

Plaque index (PI) / oral hygiene · Critically ill patients (adults and children) receiving mechanical ventilation in ICU
1 finding from 1 review

Integrated Chinese and Western medicine (incl. oral prednisone) vs Western medicine (incl. oral prednisone)

Clinical score · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review